alexa Changes in the GLUT4 Expression by Acute Exercise, Exercise Training and Detraining in Experimental Models
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Review Article

Changes in the GLUT4 Expression by Acute Exercise, Exercise Training and Detraining in Experimental Models

Alexandre M Lehnen1,2, Kátia De Angelis3, Melissa Medeiros Markoski1 and Beatriz D´Agord Schaan1,2*

1Laboratório de Experimentação Animal e Laboratório de Cardiologia Molecular e Celular do Instituto de Cardiologia do RS/Fundação Universitária de Cardiologia do Rio Grande do Sul, Porto Alegre, Brasil

2Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil

3Universidade Nove de Julho, São Paulo, Brasil

*Corresponding Author:
Beatriz D´Agord Schaan
Serviço de Endocrinologia
Hospital de Clínicas de Porto Alegre, Centro de Pesquisas
4° andar, Av. Ramiro Barcelos, 2350
Santa Cecília, 90035-903 Porto Alegre – RS Brasil
E-mail: [email protected]

Received date June 15, 2012; Accepted date July 17, 2012; Published date July 21, 2012

Citation: Lehnen AM, Angelis KD, Markoski MM, Schaan BDA (2012) Changes in the GLUT4 Expression by Acute Exercise, Exercise Training and Detraining in Experimental Models. J Diabetes Metab S10:002. doi:10.4172/2155-6156.S10-002

Copyright: © 2012 Lehnen AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



There is a direct correlation between an increase in insulin sensitivity and increased cell surface GLUT4 content. Acute exercise promotes glucose-transport stimulation that is independent of AMPK and CaMKII insulin-signaling. In turn, post-exercise glucose uptake occurs through changes in components of the insulin signaling cascade involving alterations in downstream mediators such as TBC1D1, TBC1D4/AS160 and p38 MAPK. However, the effects of acute exercise can be reversed within 18–24 hours and appear to be dependent on muscle glycogen levels. Exercise training results in adaptations that facilitate insulin-mediated glucose uptake and are regulated by different mechanisms. It leads to changes in gene expression and greater blood flow and signaling and changes in GLUT4 protein exocytosis and endocytosis. But when exercise training is discontinued GLUT4 tend to return to baseline levels. We have demonstrated in our laboratory that one-week detraining is sufficient to reduce GLUT4 in the heart and adipocytes while this same effect was seen in the gastrocnemius muscle within 2 weeks of training. The present study aimed to review how acute exercise, exercise training, and detraining affect mainly GLUT4 translocation to the insulin-sensitive cell surface.


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