alexa Changes on QT, Qtc and P Dispersion during Flexible Bronchoscopy under Propofol and 12121 Remifentanil Sedation. A Double-Blind Randomized Trial | OMICS International
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
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Research Article

Changes on QT, Qtc and P Dispersion during Flexible Bronchoscopy under Propofol and 12121 Remifentanil Sedation. A Double-Blind Randomized Trial

Rafi Dogan1*, Ozgur Ciftci2, Zuhal Ekici Ünsal3, Cemile Rusina Dogan3, Funda Gumus4 and Pinar Zeyneloglu1

1Baskent University, Medicine Faculty, Anesthesiology Department, Ankara, Turkey

2Baskent University, Medicine Faculty, Cardiology Department, Ankara, Turkey

3Baskent University, Medicine Faculty, Chest Diseases Department, Ankara, Turkey

4Bagcilar Teaching and Research Hospital, Anesthesiology Department, Istanbul, Turkey

*Corresponding Author:
Rafi Dogan, MD
Assistant Professor, Baskent University Hospital
Saray caddesi 42080 Konya, Turkey
Tel: +90 332 2570606
Fax: +90 332 257 0637
E-mail: [email protected]

Received date: June 04, 2012; Accepted date: August 06, 2012; Published date: August 10, 2012

Citation: Dogan R, Ciftci O, Ünsal ZE, Dogan CR, Gumus F, et al. (2012) Changes on QT, Qtc and P Dispersion during Flexible Bronchoscopy under Propofol and Remifentanil Sedation. A Double-Blind Randomized Trial. J Anesth Clin Res 3:229. doi: 10.4172/2155-6148.1000229

Copyright: © 2012 Dogan R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Serious hemodynamic alterations have been shown during flexible fiberoptic bronchoscopy (FFB). QT and P wave dispersion (QTd, Pd) may give us an significant information about cardiac status during FFB. This study aimed to compare the effect of propofol and remifentanil sedation on QTd, corrected QT dispersion (QTcd) and Pd during FFB. Method: Forty-nine ASA class I or II patients who were not pre-medicated were selected and allocated to receive either propofol 1 mg/kg (n=20) or remifentanil 1 μg/kg (n=20) and titrated to achieve Ramsey sedation score level of 5. QTd, QTcd and Pd were measured on electrocardiography baseline (T0), at the end of the infusion of drugs (T1), shortly after laryngoscopy (T2), at the end of bronchoscopy (T3) and the time of Modified Aldrete score to be achived 10 (T4) Heart rate, mean arterial pressure, respiratory rate and partial CO2 pressure in blood gas were recorded at these time points. Furthermore, recovery times (RT) were recorded

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