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Characteristics Associated to Lipodystrophy Syndrome among HIV-Infected Patients Naive and on Antiretroviral Treatment | OMICS International | Abstract
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Research Article

Characteristics Associated to Lipodystrophy Syndrome among HIV-Infected Patients Naive and on Antiretroviral Treatment

Paulo R Alencastro1, Fernando H Wolff2, Fabiana Schuelter-Trevisol3, Maria Letícia Ikeda1,3, Ajácio B. M. Brandão4, Nemora T. Barcellos2,4 and Sandra C. Fuchs2,3,4,*

1Hospital Sanatório Partenon, Rio Grande do Sul State Department of Health, Av. Bento Gonçalves, 3722, Porto Alegre, RS 90650-001, Brazil

2Postgraduate Program in Epidemiology, School of Medicine, Universidade Federal do Rio Grande do Sul, R. Ramiro Barcelos 2600, Porto Alegre, RS 90035-003, Brazil

3Postgraduate Program in Cardiology, School of Medicine, Universidade Federal do Rio Grande do Sul, R. Ramiro Barcelos 2350, Porto Alegre, RS 90035-003, Brazil

4National Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clinicas de Porto Alegre, Centro de Pesquisa Clínica, R. Ramiro Barcelos 2350, Porto Alegre, RS 90035-003, Brazil

*Corresponding Author:
Sandra C. Fuchs
Instituto de Avaliação de Tecnologias em Saúde (IATS) Centro de Pesquisa Clínica
5º andar Hospital de Clínicas de Porto Alegre
Universidade Federal do Rio Grande do Sul
Rua Ramiro Barcellos, 2350, Porto Alegre
RS, 90035-003, Brazil
Tel: +55513359-7621/3359-8420
E-mail: [email protected]

Received Date: September 03, 2012; Accepted Date: November 12, 2012; Published Date: November 22, 2012

Citation: Alencastro PR, Wolff FH, Schuelter-Trevisol F, Ikeda ML, et al. (2012) Characteristics Associated to Lipodystrophy Syndrome among HIV-Infected Patients Naïve and on Antiretroviral Treatment. J AIDS Clinic Res 3:182. doi:10.4172/2155-6113.1000182

Copyright: © 2012 Alencastro PR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: HIV-associated lipodystrophy involves changes in complex metabolic networks that are associated with increased cardiovascular risk. It has been associated with the use of combined antiretroviral treatment (cART), particularly Protease Inhibitors (PI) and thymidine analogs. This study aims to evaluate characteristics and use of ART associated with lipodystrophy, lipohypertrophy, and lipoatrophy among HIV-infected patients. Methods: A cross-sectional study was conducted in HIV-infected patients of both genders, aged 18 years or older, who sought care at an HIV/AIDS referral service for diagnostic confirmation or treatment between June 2006 and December 2008. Results: 1240 out of 1295 patients with HIV infection were included. Among patients on cART, women had a higher risk of lipohypertrophy than men, as well as a time since diagnosis of HIV greater than 6 years (versus <3 years). For lipoatrophy, age, education, lifestyle, and body mass index were associated with increased risk. Metabolic parameters were higher among patients on ART; and cART and PI use were independently associated with lipohypertrophy, lipoatrophy and lipodystrophy. The use of IPs can be regarded as responsible for 13% of the association of ART and lipodystrophy, and of 11.5% for the thymidine analogs use, independent of gender, skin color, smoking, CD4, and BMI. Conclusions: Risk factors fo


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