Characteristics of the Gut Microbiota in Obese Children with Allergic DiseasesMaksimova OV1*, Zverev VV1,2, Zaitseva EV2, Blinkova LP2 and Gervazieva VB2
- *Corresponding Author:
- Maksimova OV
I.M. Sechenov Fist Moccow State Medical University
2-4 Bolshaya Pirogovskaya st, Moscow, Russia
Received date: September 05, 2013; Accepted date: January 23, 2014; Published date: January 25, 2014
Citation: Maksimova OV, Zverev VV, Zaitseva EV, Blinkova LP, Gervazieva VB (2014) Characteristics of the Gut Microbiota in Obese Children with Allergic Diseases. J Bacteriol Parasitol 5:179. doi: 10.4172/2155-9597.1000179
Copyright: © 2014 Maksimova OV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
There are many evidences, that obesity increases the risk of asthma and atopic diseases. Therefore, misbalance in the gut microbiota is considered one of the micro ecological factors responsible for the increase of body mass and changes in energy metabolism. The aim of study was to investigate the characteristics of children gut microbiota, and to recognize relations with obesity, as well as allergic disorders. The study included patients of both sexes from 3 up to 17 years old: 43 with a Body Mass Index (BMI) from 23.16 to 40.28 with history of allergic diseases; and 24 children without allergies with BMI from 14.27 to 48.96. Children with allergic diseases we observed atopic dermatitis - 41.46%, asthma - 17.07%, allergic rhinitis -21.95%, food allergies - 9.76%. Condition of gut microbiota we evaluated by analysis of fecal samples and identification of microorganisms. Quantity of Enterococcus and Staphylococcus was higher than in children without allergies (56% vs. 33%; 44% vc. 17%, p=0,05 respectively). The proportion of S. aureus negatively correlated with BMI (r=-0.39, p=0.047) in allergic children, while in non-allergic children of group of children number of Bacteroides and Bifidobacteria negatively correlated with BMI (r=-0.53, p=0.010; r=-0.42, p=0.046 respectively), but the proportion of Clostridia positively correlated with BMI (r=0.56, p=0.006). Thus, we identified and characterized the qualitative and quantitative values of gut microbiota in obese children with allergy.