alexa Characterization and Functional Implications of Heart Rate Increase and Heart Rate Recovery on Maximal and Submaximal Exercise Capacity in Patients with Advanced Heart Failure
ISSN: 2329-9096

International Journal of Physical Medicine & Rehabilitation
Open Access

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Research Article

Characterization and Functional Implications of Heart Rate Increase and Heart Rate Recovery on Maximal and Submaximal Exercise Capacity in Patients with Advanced Heart Failure

Michel White1*, Jonathan Myers2, Marie-Claude Guertin3, Annik Fortier3, Anique Ducharme1, François Harel4, Eileen O'Meara1, Geneviève Gravel1 and Bernard Thibault1

1Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada

2VA Palo Alto Medical Center, Stanford University, Palo Alto, Canada

3Montreal Heart Institute Coordinating Center, Montreal, Quebec, Canada

4Department of Nuclear Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada

*Corresponding Author:
Dr. Michel White
Department of Medicine, Montreal Heart Institute
5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada
Tel: 514-376-3330
Fax: 514-376 1355
E-mail: [email protected]

Received Date: July 31, 2014; Accepted Date: October 24, 2014; Published Date: October 29, 2014

Citation: White M, Myers J, Guerti MC, Fortier A, Ducharme A, et al. (2014) Characterization and Functional Implications of Heart Rate Increase and Heart Rate Recovery on Maximal and Submaximal Exercise Capacity in Patients with Advanced Heart Failure. Int J Phys Med Rehabil 2:240. doi: 10.4172/2329-9096.1000240

Copyright: © 2014 White M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: Heart rate increase early after the initiation of exercise has not been characterized nor related to exercise capacity, heart rate recovery, and gas exchange analyses in patients with advanced heart failure. One hundred and forty-one patients including 121 patients randomized in the GREATER-EARTH trial were investigated. Methods: Exercise capacity was assessed using a treadmill ramp exercise protocol with gas exchange analyses, a fix-load endurance exercise protocol, and a 6-minute walk test. Heart rate increase was computed at 1-, 2- minutes, and 1/3 of exercise time while heart rate recovery was measured at 1- and 2-minutes following maximal exercise. Results: Heart rate increase early after the initiation of exercise test was not related to exercise capacity. In contrast, heart rate recovery was significantly related to maximal and submaximal exercise capacity. Among gas exchange responses, only the VE/VCO2 slope and PetCO2 at peak exercise were significantly associated with maximal but not submaximal exercise capacity. Conclusions: Heart rate increase early after the initiation of exercise yields no relationship with maximal and submaximal exercise capacity in patients with advanced heart failure. Among gas exchange parameters, only some markers of ventilatory inefficiency have significant associations with maximal exercise capacity in patients with heart failure.

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