Characterization of the Role of MicroRNAs in Hepatic Cancer Stem CellsDepeng Daia and Li-sheng Zhang*
College of Veterinary Medicine, University of Huazhong Agricultural, Wuhan 430070, P.R China
- *Corresponding Author:
- Li-sheng Zhang
College of Veterinary Medicine
University of Huazhong Agricultural
Wuhan 430070, P.R China
E-mail: [email protected]
Received Date: April 12, 2017; Accepted Date: May 08, 2017; Published Date: May 15, 2017
Citation: Daia D, Zhang LS (2017) Characterization of the Role of MicroRNAs in Hepatic Cancer Stem Cells. Chemo Open Access 6:232. doi: 10.4172/2167-7700.1000232
Copyright: © 2017 Daia D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Liver cancer is one of the most malignant tumors and is prone to relapse, metastasis and drug resistance. These phenomena can be explained by the existence of cancer stem cells (CSCs). CSCs have a strong ability to proliferate, are highly carcinogenic, exhibit multi-directional differentiation, develop drug resistance, and play critical roles in tumor radiotherapy, chemotherapy and tumor recurrence. miRNAs exert effects on oncogenes and tumor suppressor genes. There are distinctive miRNA expression profiles in different types of tumors, and these profiles are closely related to tumorigenesis, differentiation, metastasis and prognosis. Studies have shown that miRNAs are abnormally expressed in hepatocellular carcinoma and have important regulatory effects on the self-renewal and differentiation of hepatic cancer stem cells (HCSCs) as well as on the initiation of tumorigenesis. Therefore, it is critical to understand the impact of miRNAs in HCSC and the associated molecular mechanisms to develop new methods for the clinical diagnosis and treatment of liver cancer.