alexa Chemical and Biological Analyses of the Role of the Poly- Para- Phenylenediamine in the Erythrocytes Resistance in Hypotonic Environment | OMICS International | Abstract
ISSN: 2155-9589

Journal of Membrane Science & Technology
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Research Article

Chemical and Biological Analyses of the Role of the Poly- Para- Phenylenediamine in the Erythrocytes Resistance in Hypotonic Environment

Srhayri R1*, Naimi Y1, Takky D1, Motaouakkil S2 and Habti N3,4

1Laboratory of Physical Chemistry and Materials, Faculty of Science Ben M'sik, Hassan II University Mohammedia, Casablanca, Morocco

2Laboratory of Experimental Medicine, Faculty of Medicine and Pharmacy, University Hassan II Ain Chock, Casablanca, Morocco

3Laboratory of Hematology and Genie Genitique and Cell Engineering, Faculty of Medicine and Pharmacy, Hassan I Ain Chock University, Casablanca, Morocco

4National Center of Blood Transfusion, Morocco

*Corresponding Author:
Srhayri R
Laboratory of Physical Chemistry and Materials
Faculty of Science Ben M'sik, Hassan II University Mohammedia
Casablanca, Morocco
E-mail: [email protected]

Received date: December 19, 2015; Accepted date: January 09, 2016; Published date: January 17, 2015

Citation: Srhayri R, Naimi Y, Takky D, Motaouakkil S, Habti N (2016) Chemical and Biological Analyses of the Role of the Poly- Para-Phenylenediamine in the Erythrocytes Resistance in Hypotonic Environment. J Membra Sci Technol 6:141. doi:10.4172/2155-9589.1000141

Copyright: © 2016 Srhayri R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The high chemical and biological reactivity of para-phenylenediamine (pPD) has been illustrated in several studies, including polymerization genotoxicity and oxidative stress at the level of the plasma membrane cells. However, its reactivity with red blood cells (RBC) was rarely explored. The aim of this study is to help expound the molecular actions of para-phenylenediamine in hypotonic environment of human red blood cells by conducting biological tests for the globular resistance and physicochemical cyclic voltammetry and UV-visible spectroscopy. Our results show that the para-phenylenediamine at low concentration gives red blood cells temporary resistance (30 min) against hemolysis in hypotonic environment with 4.5 g/L NaCl. Spectrometry results for UVvisible and cyclic voltammetry suggest that membrane stability is due to the presence of the polymer poly-paraphenylenediamine (poly-pPD).


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