Chemical Approach to Signal Transduction by Inositol Triphosphate
The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
- *Corresponding Author:
- Shoichiro Ozaki
The Institute of Physical and Chemical Research
2-1 Hirosawa, Wako, Saitama 351-0198, Japan
E-mail: [email protected]
Received Date: September 15, 2014; Accepted Date: September 24, 2014; Published Date: October 04, 2014
Citation: Ozaki S (2014) Chemical Approach to Signal Transduction by Inositol Triphosphate. J Bioengineer & Biomedical Sci 4: 133. doi: 10.4172/2155-9538.1000133
Copyright: © 2014 Ozaki S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Berridge discovered that inositol 1,4,5-trisphophate (IP3) was generated at the cell surface in response to cell stimulation and functioned as a second messenger to release Ca2+ from internal stores. Ozaki et al. succeeded in the first total synthesis of optically active IP3 by 13 steps. He supported the signal transduction studies by supplying necessary reagents such as IP3, other IPx, phosphatidyl inositol, new synthetic methods and reagents. He discovered the regulators of Ca2+ release and consequent cellular processes.