alexa Chemical Biology Approach for Dissection of RNAi/miRNA Pathway
ISSN: 2168-9849

Cloning & Transgenesis
Open Access

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Review Article

Chemical Biology Approach for Dissection of RNAi/miRNA Pathway

Peng Ji and Yujing Li*
Department of Human Genetics, Emory University School of Medicine, USA
Corresponding Author : Yujing Li
Department of Human Genetics
Emory University School of Medicine
615 Michael St, Atlanta, USA
E-mail: [email protected]
Received February 27, 2013; Accepted March 12, 2013; Published March 15, 2013
Citation: Ji P, Li Y (2013) Chemical Biology Approach for Dissection of RNAi/miRNA Pathway. Clon Transgen 2:105. doi:10.4172/2168-9849.1000105
Copyright: © 2013 Ji P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

RNA interference (RNAi)/miRNA has been recognized as one of the most important regulation mechanisms of gene expression at posttranscriptional levels in eukaryotic cells. Although the main components within the RNAi/ miRNA pathway have been identified and characterized, studies on the molecular mechanisms regulating the activity of the RNAi/miRNA pathway have begun to emerge in recent years. High-throughput reporter assays have been developed to monitor the activity of the RNAi/miRNA pathway and applied for proof-of-concept pilot screening, leading to identification of some inhibitors and activators that are generally or specifically regulate activity of the RNAi/ miRNA pathway. Additionally, in combination with multidisciplinary approaches such as proteomics, biochemistry and genetics, to identify the targeting components, some protein co-factors that to play significant roles in the regulation of the activity of the RNAi/miRNA pathway have been identified. Herein we highlight the high throughput reporter assays developed in recent years and the resulting discovery of the RNAi/miRNA enhancers and inhibitors, with attention on developing novel RNAi- or miRNA-based therapeutic interventions.

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