alexa Chemical Composition and Antibacterial Activity of Vola
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Research Article

Chemical Composition and Antibacterial Activity of Volatile Oil of Sequoia sempervirens (Lamb.) Grown in Egypt

Taha KF and Shakour ZTA*
Laboratory of Phytochemistry, National Organization for Drug Control and Research, Cairo, Egypt
*Corresponding Author : Shakour ZTA
Laboratory of Phytochemistry
National Organization for Drug Control and Research
Cairo 11364, Egypt
Tel: 01274885786
E-mail: [email protected]
Received: March 03, 2016; Accepted: March 29, 2016; Published: April 04, 2016
Citation: Taha KF, Shakour ZTA (2016) Chemical Composition and Antibacterial Activity of Volatile Oil of Sequoia sempervirens (Lamb.) Grown in Egypt. Med Aromat Plants 5:245. doi:10.4172/2167-0412.1000245
Copyright: © 2016 Taha KF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The hydrodistilled essential oil of leaves of Sequoia sempervirens (Lamb.) belonging to family Cupressaceae was analyzed by GC/MS. Thirty six compounds were identified representing 95.62% of the total oil containing α-phellandrene (29.60%), dl-limonene (15.60%), α-pinene (8.65%) and terpinene-4-ol (3.5%) as major components. The studied essential oil showed a dose-dependent antioxidant activity using 2, 2-diphenyl-1-picrylhydrazyl assay (IC50: 32.2 μg/mL). The antimicrobial activity of S. sempervirens leaves oil was screened against Gram-positive and Gram-negative bacteria and fungi. The strongest antibacterial effects of oil were on Bacillus subtilis, Trichophyton mentagrophytes and Staphylococcus aureus. S. sempervirens oil showed potent cytotoxic activity against the tested carcinoma cell lines; hepatocellular (HEPG2), colon adenocarcinoma (HCT-116) and breast (MCF7) comparing to doxorubicin.

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