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ISSN: 2161-0495

Journal of Clinical Toxicology
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Research Article

Chemical Composition and Biological Screening of Essential Oils of Zanthoxylum armatum DC Leaves

Barkatullah1, Muhammad Ibrar1, Naveed Muhammad*2, Innayat- Ur- Rehman3, Mujeeb-Ur-Rehman4, and Ajmal Khan4

1Department of Botany, University of Peshawar, Peshawar-25120, KPK, Pakistan

2Department of Pharmacy, Abdul Wali Khan University Mardan, KPK, Pakistan.

3PCSIR laboratories complex, Peshawar, Pakistan

4H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan

*Corresponding Author:
Naveed Muhammad
Department of Pharmacy
Hazara University, Havelian Campus
Abbottabad, Pakistan
E-mail: [email protected]

Received date: August 17, 2013; Accepted date: October 08, 2013; Published date: October 20, 2013

Citation: Barkatullah, Ibrar M, Muhammad N, Ur- Rehman I, Rehman MU, et al.(2013) Chemical Composition and Biological Screening of Essential Oils of Zanthoxylum armatum DC Leaves. J Clin Toxicol 3:172. doi: 10.4172/2161-0495.1000172

Copyright: © 2013 Barkatullah, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Essential oil (ZVO) from Zanthoxylum armatum was extracted through hydro-distillation and tested for various biological activities. A total of 34 chemical constitutes were identified through GC-MS, the major constituents of ZVO were beta- Linalool (53.05%), Bergamot mint oil (12.73%), alpha-Limonene diepoxide (11.39%), alpha- pinene (4.08%), beta- Myrcene (3.69%) and D-Limonene (3.10%). ZVO showed significant antispasmodic effect and relaxed the isolated rabbit jejunum in spontaneous as well as in potassium chloride induced contraction. The maximum effect was observed against M. leutus followed by B. subtilis with percent zone of inhibition 28.45 and 20.45, respectively. A concentration dependent effect was also observed against available species of fungi. The maximum effect was observed against M. canis, C. albicans and C. glabrata with percent activity 84.87, 83 and 79, respectively. The oils were also found to have Cytotoxic and Phytotoxic potential.

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