Chemical Modifier Screenings as Methods for Identifying Pathway-Targeting Compounds and for Predicting Drug-Drug Interactions
Received Date: Apr 16, 2014 / Accepted Date: Aug 11, 2014 / Published Date: Aug 15, 2014
Screenings for genetic modifiers, such as suppressors or enhancers, in model organisms have identified and characterized important signaling pathways. Likewise, a phenotype induced by a chemical compound can be suppressed or enhanced by another compound. Here, I introduce chemical modifier screenings as phenotype-based assays that expand therapeutic targets to unexpected molecules and that facilitate identification of target signaling pathways. Also, chemical modifier screening can be applied to predicting possible drug-drug interactions that cause adverse effects.
Keywords: Chemical suppressor; Chemical enhancer; Pathway targeting; Drug-drug interaction
Citation: Nishiya N (2014) Chemical Modifier Screenings as Methods for Identifying Pathway-Targeting Compounds and for Predicting Drug-Drug Interactions. Organic Chem Curr Res 3: 128. Doi: 10.4172/2161-0401.1000128
Copyright: © 2014 Nishiya N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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