alexa Chemical Modifier Screenings as Methods for Identifying Pathway-Targeting Compounds and for Predicting Drug-Drug Interactions | OMICS International| Abstract

ISSN: 2161-0401

Organic Chemistry: Current Research

  • Research Article   
  • Organic Chem Curr Res 2014, Vol 3(2): 128
  • DOI: 10.4172/2161-0401.1000128

Chemical Modifier Screenings as Methods for Identifying Pathway-Targeting Compounds and for Predicting Drug-Drug Interactions

Naoyuki Nishiya*
Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University, School of Pharmacy, Japan
*Corresponding Author : Naoyuki Nishiya, Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University, School Of Pharmacy 2-1-1 Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate, 028-3694, Japan, Tel: +81-19-651- 5111, Fax: +81-19-698-1841, Email: [email protected]

Received Date: Apr 16, 2014 / Accepted Date: Aug 11, 2014 / Published Date: Aug 15, 2014

Abstract

Screenings for genetic modifiers, such as suppressors or enhancers, in model organisms have identified and characterized important signaling pathways. Likewise, a phenotype induced by a chemical compound can be suppressed or enhanced by another compound. Here, I introduce chemical modifier screenings as phenotype-based assays that expand therapeutic targets to unexpected molecules and that facilitate identification of target signaling pathways. Also, chemical modifier screening can be applied to predicting possible drug-drug interactions that cause adverse effects.

Keywords: Chemical suppressor; Chemical enhancer; Pathway targeting; Drug-drug interaction

Citation: Nishiya N (2014) Chemical Modifier Screenings as Methods for Identifying Pathway-Targeting Compounds and for Predicting Drug-Drug Interactions. Organic Chem Curr Res 3: 128. Doi: 10.4172/2161-0401.1000128

Copyright: © 2014 Nishiya N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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