Chemically Modified Carbon Sensors Mixed or Single for the Determination of Cardiovascular Drug Nafronyl Oxalate in Bulk, Praxilene and Human FluidsAmal F Khorshid*
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Nahda University, NUB, Beni-Sueff, Egypt
- *Corresponding Author:
- Amal Khorshid F
Pharmaceutical Analytical Chemistry Department
Faculty of Pharmacy, Nahda University
NUB, Beni-Sueff, Egypt
E-mail: [email protected]
Received Date: May 24, 2014; Accepted Date: June 13, 2014; Published Date: June 20, 2014
Citation: Khorshid AF (2014) Chemically Modified Carbon Sensors Mixed or Single for the Determination of Cardiovascular Drug Nafronyl Oxalate in Bulk, Praxilene and Human Fluids. J Biosens Bioelectron 5: 153. doi: 10.4172/2155-6210.1000153
Copyright: © 2014 Khorshid AF. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Three novel chemically modified Carbon Paste Sensors (CMCPs) were proposed for the determination of nafronyl potentiometric in bulk, pharmaceutical dosage form; human plasma/urine. The sensors were based on an ion-pair associates of nafronyl silicotungstic acid (Nf-St) (sensor 1), nafronyl silicomolybdic acid (Nf-SM) (sensor 2), a mixture of (Nf-St)+(Nf-SM) (sensor 3). The modified sensors showed Nernstian slopes ranging from 58.5 ± 0.5-60.7 ± 0.5 mV over the concentration ranged from 1.0x10-7-1.0x10-2 M and pH 2.0-6.0 with detection limit 0.1 nM. The sensors exhibited good selectivity for nafronyl with respect to inorganic/organic cations, sugars and amino acids. The calibration curve, standard addition and potentiometric titration methods were applied for the determination of nafronyl ion in its bulk powder, pharmaceutical dosage form, and human fluids plasma/urine taken from a healthy volunteer and for the monitoring Praxilene tablets in vitro dissolution rates. Sensor 3 had been the best sensitivity so was successfully used for the determination the solubility products of ion-pair associates. The results were excellent and satisfactory recovery comparable to those obtained with the British Pharmacopoeia.