alexa
Reach Us +44-1647-403003
Chemoprevention in Sporadic Colorectal Cancer: The Role of Salycilates,Nsaids and Coxibs | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Chemoprevention in Sporadic Colorectal Cancer: The Role of Salycilates,Nsaids and Coxibs

Manzano A and Pérez-Segura P*

Department of Oncology, Hospital Clínico San Carlos, Madrid, Spain

*Corresponding Author:
Pérez-Segura P
Department of Oncology
Hospital Clínico San Carlos
Madrid, Spain
E-mail: [email protected]

Received Date: November 15, 2011; Accepted Date: December 13, 2011; Published Date: December 15, 2011

Citation: Manzano A, Pérez-Segura P (2011) Chemoprevention in Sporadic Colorectal Cancer: The Role of Salycilates, Nsaids and Coxibs. J Cancer Sci Ther S3:005. doi: 10.4172/1948-5956.S3-005

Copyright: © 2011 Manzano A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Sporadic colorectal cancer (CRC) represents 75% of the total of the CRC cases diagnosed and is the second leading cause of cancer death with a a 5-year survival rate of 62%. The development of colorectal cancer is a complex process involving multiple molecular pathways, since the formation of adenomas to the development of carcinoma in the digestive tract (the so-called “adenoma-carcinoma sequence”), in a process that can last several decades. Thus adenomas are considered a surrogate variable for the development of CRC in clinical trials. Although screening strategies (blood in stool, endoscopic and CT-colonoscopy) have supposed a great advance in the early detection of these tumours, they are associated with inconveniences such as their cost and associated morbidity. Moreover screening does not necessarily prevent the development of cancer or prevent mortality. Therefore, interest in primary prevention research has increased in recent years. In this regard, multiple attempts to modify lifestyle and dietary factors to try to reduce the incidence of cancer have been promoted. However, some studies, many of them observational or case-control, have yielded conflicting data. Consequently, in the past 20 years, chemoprevention studies have grown in importance.

Share This Page
Top