alexa Chernobyl-Touched Children: E and A Hypovitaminoses-Related Mechanisms and Prevention of Radiogenic Mutagenicity and Teratogenicity
ISSN: 2376-1318

Vitamins & Minerals
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Research Article

Chernobyl-Touched Children: E and A Hypovitaminoses-Related Mechanisms and Prevention of Radiogenic Mutagenicity and Teratogenicity

Eugene Neyfakh1*, Aigule Alimbekova1 and Igor Suskov2
1 Semenov N, Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
2 Vavilov N, Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
Corresponding Author : Eugene Neyfakh
Inst. of Chemical Physics RAS
Moscow, Russia
Tel: +495-9397475
Fax: +499-1374101
E-mail: [email protected]
Received November 16, 2013; Accepted December 24, 2013; Published December 30, 2013
Citation: Neyfakh E, Alimbekova A, Suskov I (2013) Chernobyl-Touched Children: E and A Hypovitaminoses-Related Mechanisms and Prevention of Radiogenic Mutagenicity and Teratogenicity. Vitam Miner 3:117. doi:10.4172/2376-1318.1000117
Copyright: © 2013 Neyfakh E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Children and their mothers affected by the Chernobyl catastrophy suffer with toxic lipoperoxic stress coupled with hypovitaminoses A and E. The relation of these primary biochemical disturbances to notorious somatic consequences on mutagenic and teratogenic levels caused by chronic low-dose radiation of children from radiopolluted regions had been investigated. Rational approaches to prevent or to treat indicated pathologies were developed either. Vitamins A and E blood levels for newborns from radio polluted regions were near a third of normal ones. Simultaneous increasing of lipo-peroxidation for studied children had tendency to correlate with their body stigmation. Radiogenic indices of mutagenicity and teratogenicity showed dramatic increases along with fall of the essential antioxidants. The peroral poly vitamin therapy of women at the beginning of 1st trimester pregnancy prevented or corrected evaluated abnormalities for their newborns. Vitamin-protected children had normal ranges for studied indices. The combination of radiogenic biochemical deviations is supposed to be the primary molecular mechanisms for children restorable somatic hyper mutations and irreversible body stigmations but preventable by essential antioxidants via their mothers at early pregnancy.

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