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ISSN: 2161-0959

Journal of Nephrology & Therapeutics
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Research Article

Children with Nephrotic Syndrome Suffer from Cerebral Venous Thrombosis

Zheng-Kun Xia*, Xiao Yang*, Zhong-Min Fan*, Yuan-Fu Gao*, Chunlin Gao, Jing Li, Xu He, Pei Zhang, Tao Sun, Zhuo Shi, Hongjun Peng
and Min Xu

Department of Pediatrics, Nanjing Jinling Hospital, China

*Corresponding Author:
Zheng-Kun Xia
Department of Pediatrics
Nanjing Jinling Hospital
305 East Road, Zhong Shan
Nanjing 210002, P.R. China
Tel: (+86 25) 80861386
E-mail: [email protected]

Xiao Yang
Department of Pediatrics
Nanjing Jinling Hospital
305 East Road ZhongShan
Nanjing 210002,P.R.China
Tel: (+86 25) 80861386
E-mail: [email protected]

Zhongmin Fan
Department of Pediatrics
Nanjing Jinling Hospital
305 East Road ZhongShan
Nanjing 210002,P.R.China
Tel: (+86 25) 80861386
E-mail: [email protected]

Yuanfu Gao
Department of Pediatrics
Nanjing Jinling Hospital
305 East Road ZhongShan
Nanjing 210002,P.R.China
Tel: (+86 25) 80861386
E-mail: [email protected]

Received Date: January 03, 2014; Accepted Date: February 18, 2014; Published Date: February 25, 2014

Citation: Xia ZK, Yang X, Fan ZM, Gao YF, Gao C, et al. (2014) Children with Nephrotic Syndrome Suffer from Cerebral Venous Thrombosis. J Nephrol Therapeutic S11:005. doi:10.4172/2161-0959.S11-005

Copyright: © 2014 Xia ZK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hypercoagulability is a common complication in children with nephrotic syndrome and may cause venous thrombosis. This study explored the effectiveness of urokinase and low-molecular-weight (LMW) heparin used in conjunction in seven children with nephrotic syndrome complicated by intracranial venous thrombosis. The urokinase dose was 2,000-4,000 u/kg/day initially, with a pulse dose of 20,000-40,000 u given within 15-30 minutes and the remainder was pump-infused. From day 2, a dose of 2,000 u/kg/day was infused via the pump, and the total course duration was 3 to 7 days. During treatment, thrombin time (TT) and activated partial thromboplastin time (APTT) were tested three times per week, and particular attention was given to any bleeding. LMW heparin was used at a dosage of 100-120 anti-Xa IU/kg once or twice per day, given by abdominal subcutaneous injection for two weeks. The antiplatelet drug, dipyridamole 3-5 mg/kg, was also given orally two or three times per day for three months. In this study, the early use of urokinase, LMW heparin and anti-platelet drugs had good effect, the need for preventive therapy and early diagnosis of this complication in nephrotic syndrome should be given wider clinical consideration.

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