alexa Chimerism and Tolerance in Solid Organ Transplantation
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Chimerism and Tolerance in Solid Organ Transplantation

Kadiyala Ravindra1, Joseph Leventhal2, David Song3 and Suzanne T. Ildstad3*
1Duke University, Durham, NC, USA
2Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL, USA
3Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA
Corresponding Author : Suzanne T. Ildstad, M.D.
Director, Institute for Cellular Therapeutics
Jewish Hospital, Distinguished Professor of Transplantation
Distinguished University Scholar, Professor of Surgery
University of Louisville, 570 South Preston Street
Suite 404, Louisville, Kentucky 40202-1760, USA
Tel: 502-852-2080
Fax: 502-852-2079
E-mail: [email protected]
Received October 01, 2012; Accepted October 22, 2012; Published October 29, 2012
Citation: Ravindra K, Leventhal J, Song D, Ildstad ST (2012) Chimerism and Tolerance in Solid Organ Transplantation. J Clin Cell Immunol S9:003. doi:10.4172/2155-9899.S9-003
Copyright: © 2012 Ravindra K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Transplantation has become standard of care to treat end-organ failure, replacing a failed organ with a functioning one. However, the toxicity of the immunosuppressive agents that are critical to graft maintenance is significant. Complications associated with the use of these agents include opportunistic infections, cardiovascular disorders, an increased rate of malignancy, and renal failure. As a result, approaches to induce tolerance to transplanted organs and/or minimize immunosuppression are a major priority. This review summarizes the role of chimerism in tolerance induction, presenting an historic perspective and ending on clinical protocols actively underway.

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