alexa Cholesterol as a Mediator of Alcohol-Induced Risks for Respiratory Disease Hospitalizations among People Living With HIV
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Research Article

Cholesterol as a Mediator of Alcohol-Induced Risks for Respiratory Disease Hospitalizations among People Living With HIV

María José Míguez1*, Rhonda Rosenberg2, Ximena Burbano3 and Robert Malow4

1Associate Professor, School of Integrated Sciences and Humanity, Florida International University, Miami, FL, USA

2Department of Health Promotion and Disease Prevention, Robert Stempel College of Public Health and Social Work and College of Medicine and School of Medicine, Florida International University, Miami, FL, USA

3School of Integrated Sciences and Humanity, Florida International University, Miami, FL, USA

4Professor, Department of Health Promotion and Disease Prevention, Robert Stempel College of Public Health and Social Work and College of Medicine and School of Medicine, Florida International University, Miami, FL, USA

*Corresponding Author:
Maria Jose Miguez-Perez
Associate Professor
School of Integrated Sciences and Humanity
Florida International University, Miami, FL, USA
E-mail: [email protected]

Received Date: May 15, 2011; Accepted Date: October 18, 2011; Published Date: October 21, 2011

Citation: Míguez MJ, Rosenberg R, Burbano X, Malow R (2011) Cholesterol as a Mediator of Alcohol-Induced Risks for Respiratory Disease Hospitalizations among People Living With HIV. J AIDS Clinic Res S1:001. doi:10.4172/2155-6113.S1-001

Copyright: © 2011 Míguez MJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We analyzed the role of cholesterol as a potential mediator of alcohol-increased risk of respiratory infections that required hospitalization in People Living with HIV (PLWH). Using a longitudinal clinic-based design, 346 PLWH were consecutively admitted and followed at Jackson Memorial Medical Center(enrolled in the study). Following national guidelines, PLWH were stratified according to cholesterol levels: <150 mg/dl (Hypocholesterolemia= HypoCHL), 151-200, and >200 mg/dl Hypercholesterolemia =HyperCHL), and compared on the basis of clinical outcomes, lymphocyte phenotypes and behavioral risks. Analyses indicated that compared to HyperCHL participants, HypoCHL subjects were more likely to be hospitalized, particularly for lower respiratory tract infections (LRTI). Excessive admissions were associated with more deviant lymphocyte profiles, particularly limited NK cells. In logistic regression analyses, smoking (OR=1.5), HypoCHL (OR=7.7), and alcohol (OR=1.2) were predictors of LRTI. These findings warrant further investigation of the potential use of HypoCHL as a risk marker, and the cost-effectiveness of switching prevention gears towards HypoCHL, alcohol and tobacco in PLWH.

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