Chondrogenic Progenitor Cells and Articular Cartilage RepairConstance R Chu* and Nicole Friel
Department of Orthopedic Surgery, University of Pittsburgh, USA
- *Corresponding Author:
- Constance R Chu
Department of Orthopedic Surgery
KAU 911, USA
E-mail: [email protected]
Received date: February 21, 2012; Accepted date: April 27, 2012; Published date: April 30, 2012
Citation: Chu CR, Friel N (2012) Chondrogenic Progenitor Cells and Articular Cartilage Repair. Rheumatol Curr Res S3:006. doi: 10.4172/2161-1149.S3-006
Copyright: © 2012 Chu CR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Treatment of articular cartilage injury is challenging due in part to the paucity of potential repair cells within articular cartilage. While chondrocytes can be expanded in culture and returned to the site of injury, autologous applications require removal of healthy articular cartilage - a limited resource. Additional sources of chondrogenic progenitor cells that may be suitable for articular cartilage repair include Mesenchymal Stem Cells (MSCs) isolated from more abundant tissues such as bone marrow, synovium, infrapatellar fat pad, subcutaneous fat, periosteum,perichondrium, and muscle.