alexa Chondromyxoid Fibroma of the Femur Can Not Be Differentiated ofrm Chondrosarcoma by 18F-FDG PET/CT, and Histopathology is Still the Final Diagnsotic Tool
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Chondromyxoid Fibroma of the Femur Can Not Be Differentiated ofrm Chondrosarcoma by 18F-FDG PET/CT, and Histopathology is Still the Final Diagnsotic Tool

Taishi Okada, Hiroyuki Futani*, Ryo Kanto, Shunsuke Kumanishi, Yoshitane Tsukamoto and Shinichi Yoshiya
Department of Orthopaedic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
Corresponding Author : Hiroyuki Futani
Department of Orthopaedic Surgery, Hyogo College of Medicine
Nishinomiya, Hyogo, Japan
Tel: + 81 798 45 6452
Fax: + 81 798 45 6453
E-mail: [email protected]
Received: November 12, 2015 Accepted: December 14, 2015 Published: December 21, 2015
Citation: Okada T, Futani H, Kanto R, Kumanishi S, Tsukamoto Y, et al. (2015) Chondromyxoid Fibroma of the Femur Can Not Be Differentiated from Chondrosarcoma by 18F-FDG PET/CT, and Histopathology is Still the Final Diagnostic Tool. J Clin Case Rep 5:661. doi:10.4172/2165-7920.1000661
Copyright: © 2015 Okada T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Chondromyxoid fibroma is an extremely rare, benign cartilaginous tumor, which might be misdiagnosed as hondrosarcoma. Recent studies reported that PET/CT could distinguish benign cartilaginous tumors from chondrosarcomas with maximum Standardized Uptake Value (SUVmax) of more than 2.0. In the literature, 4 cases of chondromyxoid fibroma have been reported on PET/CT with high accumulation of 18FFDG. However, no paper has explained the reason for this high accumulation. In this paper, we present a case of femoral chondromyxoid fibroma and discuss the rational reason for high accumulation of 18F-FDG by PET/CT in accordance with histology. Here, a 20-year-old female presented with a lesion located in the medial aspect of the left distal femur. Radiography revealed an eccentric radiolucency in the metaphysis of the left distal femur. CT images clearly demonstrated a cortical destruction of the posterior wall. PET/CT images clearly demonstrated an abnormal 18F-FDG uptake of the distal aspect of the left femur with SUVmax value of 6.6, indicating a chondrosarcoma. In the present case, histology showed a number of multinucleated giant cells at the periphery of the lobules in the tumor, which can explain the high accumulation.

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