Choroidal Thickness Values Following the Consumption of Sildenafil and Tadalafil: Comparison of the OCT RecordsMarilita M Moschos* and Eirini Nitoda
1st Department of Ophthalmology, Medical School, National & Kapodistrian University of Athens, Greece
- *Corresponding Author:
- Marilita M. Moschos
1st Department of Ophthalmology, Medical School
National & Kapodistrian University of Athens
6 Ikarias Street, Ekali, 14578, Athens, Greece
E-mail: [email protected]
Received date: July 05, 2016; Accepted date: August 12, 2016; Published date: August 16, 2016
Citation: Moschos MM, Nitoda E (2016) Choroidal Thickness Values Following the Consumption of Sildenafil and Tadalafil: Comparison of the OCT Records. J Clin Exp Ophthalmol 7:592. doi:10.4172/2155-9570.1000592
Copyright: © 2016 Moschos MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: The aim of this study is to demonstrate the anatomic and physiologic changes in the choroid following systemic sildenafil and tadalafil.
Methods: This cross-sectional randomized study enlisted 20 young and healthy men, who were randomly and equally classified in two groups; group a received 50 mg of Sildenafil, whereas group B received 10 mg of Tadalafil. All participants underwent a measurement of choroidal thickness, based on enhanced depth imaging optical coherence tomography (EDI-OCT). The measurement was repeated two hours after the consumption of each PDE-5 inhibitor.
Results: The mean age of participants was 34.2 ± 3.0 and 34.6 ± 3.2 years in group A and B, respectively. The mean values of choroidal thickness (CT) in Group A at baseline were 306.6 ± 11.1 μm, 229.9 ± 12.7 μm and 311.3 ± 21.8 μm in temporal, nasal and inferior quadrants, respectively. The mean increase in choroidal thickness in Group A two hours after receiving sildenafil was 29.9 μm, 23.8 μm and 34.2 μm in temporal (CI [-35.18,-24.62], p<0.001), nasal (CI [-27.20,-20.40], p<0.001) and inferior (p=0.005) quadrants, respectively. On the other hand, the mean values of choroidal thickness in Group B at baseline were 307.2 ± 10.6 μm, 227.4 ± 8.9 μm and 315.8 ± 9.1 μm in temporal, nasal and inferior quadrants, respectively. Significant raise was also noted in Group B two hours after tadalafil intake in temporal (13.2 μm, CI [-17.77,-8.63], p<0.001), nasal (12.7 μm, CI [-14.75,-10.65], p<0.001) and inferior (15.6 μm, CI [-17.36,-13.84], p<0.001) quadrants, respectively. The increment in choroidal thickness observed after the intake of PDE-5 inhibitors was greater in group A and this difference exhibited statistical significance (independent samples t-test, CT temporal: t(18)=5.338, p<0.001, 95%CI [9.95, 22.85], Levene's test: p=0.791, CT nasal: t(18)=6.332, p<0.001, 95%CI [7.48, 14.92], Levene's test: p=0.088, Mann-Whitney test, CT inferior: p<0.001).
Conclusion: Both sildenafil and tadalafil resulted in the increment of choroidal thickness, but tadalafil caused a lower increase. This alteration could secondary affect retinal function or be a useful adjunct whenever increase choroidal blood flow is demanded.