Chronic Neutrophilic Leukemia: A Rare and Difficult Diagnosis of ExclusionJames Ziai1,2, Richard Torres1,2 and Christopher A. Tormey1,2*
- *Corresponding Author:
- Dr. Christopher A. Tormey
Assistant Professor of Laboratory Medicine
Yale University School of Medicine, 333 Cedar Street
PO Box 208035, New Haven, USA
Tel: 203-932-5711 ext. 2964
E-mail: [email protected]
Received date: September 28, 2010; Accepted date: November 11, 2010; Published date: November 13, 2010
Citation: Ziai J, Torres R, Tormey CA (2010) Chronic Neutrophilic Leukemia: A Rare and Difficult Diagnosis of Exclusion. J Blood Disord Transfus 1:102. doi: 10.4172/2155-9864.1000102
Copyright: © 2010 Ziai J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Chronic neutrophilic leukemia (CNL) is an extremely rare myeloproliferative disorder that presents diagnostic challenges for both pathologists and treating clinicians. Because this disease entity is very rare, and because it is typically a diagnosis of exclusion, it is important for pathologists and hematologists to be familiar with CNL when approaching the patient with a myeloproliferative clinical picture. Thus, the objectives of this report are: 1) to detail the clinical case of a 59 year old male veteran with initial presentation of hyperleukocytosis, 2) to review the differential diagnosis of a granulocytic myeloproliferative presentation and demonstrate the laboratory and clinical criteria utilized to establish a diagnosis of CNL in this case, and 3) to briefly review the current literature on the diagnosis and treatment of CNL.