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ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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Research Article

Chronic Neutrophilic Leukemia: A Rare and Difficult Diagnosis of Exclusion

James Ziai1,2, Richard Torres1,2 and Christopher A. Tormey1,2*

1Pathology and Laboratory Medicine Service, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT USA

2Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208035, New Haven, CT USA

*Corresponding Author:
Dr. Christopher A. Tormey
Assistant Professor of Laboratory Medicine
Yale University School of Medicine, 333 Cedar Street
PO Box 208035, New Haven, USA
Tel: 203-932-5711 ext. 2964
Fax: 203-937-4746
E-mail: [email protected]

Received date: September 28, 2010; Accepted date: November 11, 2010; Published date: November 13, 2010

Citation: Ziai J, Torres R, Tormey CA (2010) Chronic Neutrophilic Leukemia: A Rare and Difficult Diagnosis of Exclusion. J Blood Disord Transfus 1:102. doi: 10.4172/2155-9864.1000102

Copyright: © 2010 Ziai J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Abstract

Chronic neutrophilic leukemia (CNL) is an extremely rare myeloproliferative disorder that presents diagnostic challenges for both pathologists and treating clinicians. Because this disease entity is very rare, and because it is typically a diagnosis of exclusion, it is important for pathologists and hematologists to be familiar with CNL when approaching the patient with a myeloproliferative clinical picture. Thus, the objectives of this report are: 1) to detail the clinical case of a 59 year old male veteran with initial presentation of hyperleukocytosis, 2) to review the differential diagnosis of a granulocytic myeloproliferative presentation and demonstrate the laboratory and clinical criteria utilized to establish a diagnosis of CNL in this case, and 3) to briefly review the current literature on the diagnosis and treatment of CNL.

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