Chronic Obstructive Pulmonary Disease and Proteomics: A Match for Success?
Bruno M. Alexandre and Deborah Penque*
Laboratório de Proteómica, Departamento de Genética, Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA-IP), Lisboa, Portugal
- *Corresponding Author:
- Deborah Penque, Ph.D
Laboratório de Proteómica
Departamento de Genética, Edifício INSA II
Instituto Nacional de Saúde Dr. Ricardo Jorge, INSA, I.P
Avenida Padre Cruz, 1649-016 Lisboa, Portugal
Fax: +35121752 6410
E-mail: [email protected]
Received Date: December 24, 2011; Accepted Date: February 22, 2012; Published Date: February 27, 2012
Citation: Alexandre BM,Penque D (2012) Chronic Obstructive Pulmonary Disease and Proteomics: A Match for Success? J Aller Ther S7:003. doi: 10.4172/2155-6121.S7-003
Copyright: © 2012 Alexandre BM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation that is not fully reversible even under bronchodilators effect, caused by a mixture of small airway disease and parenchymal destruction. COPD is a major cause of morbidity and mortality in adults, and it is now the fourth leading death cause in the world. Cigarette smoking is the main risk factor for COPD but not all smokers will suffer from COPD, suggesting that genetic and other environmental factors are involved in this pathology.
Current diagnosis is based on spirometry, but there is recurrent debate on fixed spirometric thresholds in use that lead to misdiagnosis and/or classification of COPD. The available treatments are not effective to reduce or suppress the progression of COPD. Hence, there is an urgent need to better understand the molecular mechanisms of COPD pathogenesis to provide clinicians with reliable diagnosis and treatment tools for COPD. Proteomics, defined by the comprehensive study of the proteome, has the potential to respond to this need by providing protein profiles of a particular disease and, at the same time, by identifying specific biomarkers that can be used to better understand, diagnose and manage the disease. Here, we shortly review COPD history and pathology and how proteomics can match COPD for success.