alexa Chronic Tension Type Headache, An Analog for Fibromyalgia and Depression Disorder?
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Chronic Tension Type Headache, An Analog for Fibromyalgia and Depression Disorder?

Ping Qu1, Jin-Xia Yu2, Lan Xia1 and Gui-Hai Chen3*
1Department of Neurology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
2Official Hospital of The people's Government, Anhui Province, Hefei 230001, China
3Department of Neurology, The Affiliated Chaohu Hospital of Anhui Medical University, Chaohu 238000, China
Corresponding Author : Gui-Hai Chen
Department of Neurology
The Affiliated Chaohu Hospital
of Anhui Medical University
Chaohu 238000, China
Tel: 86-0551-82324234
Fax: 86-0551-82324234
E-mail: [email protected]
Received: September 08, 2015 Accepted: October 13, 2015 Published: October 17, 2015
Citation: Qu P, Yu JX, Xia L, Chen GH (2015) Chronic Tension Type Headache, An Analog for Fibromyalgia and Depression Disorder? Biochem Pharmacol (Los Angel) 4:190. doi:10.4173/2167-0501.1000190
Copyright: © 2015 Qu P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Chronic tension type headache (CTTH) is the most prevalent headache and is associated with a high socio-economic impact. The exact pathogenesis of CTTH remains unclear. It has been shown CTTH has many similar clinic features with fibromyalgia (FM) and major depression disorder (MDD). Several studies have found some changes of hypothalamic-pituitary-adrenal (HPA) and hypothalamus-pituitary-thyroid (HPT) axes, sex hormones and pro-inflammatory cytokines in FM and MDD. We speculated CTTH has the same changes. Striving to provide new insights into the pathophysiology of CTTH, we designed this trial to address the common and specific aspects of these three disorders in their clinic features and pathophysiological mechanisms, especially from neuroendocrine system and inflammatory pathways. Method: The patients with CTTH, FM and MDD were recruited, and the healthy subjects were selected as controls. The sleep quality, depressive mood and cognitive function of all subjects were evaluated. The serum levels of corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), cortisol, thyrotrophin releasing hormone (TRH), thyroid stimulating hormone (TSH), total triiodothyronine (TT3), total thyroxine (TT4) , gonadotrophin releasing hormone (GnRH), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were detected to find the changes of neuroendocrine system and inflammatory pathways which are believed to be linked with these disorders. Results: Compared with the controls, the HAMD-17 and PSQI scores were significantly higher (Ps<0.001) and the MoCA-C score was significantly lower (P=0.029) in the CTTH, FM and MDD patients. The patients with the CTTH, FM and MDD showed different degrees of damage in spatial and object memories compared to the controls (Ps<0.05). The changes of the HPA and HPT axes, GnRH and pro-inflammatory cytokines in the CTTH, FM and MDD patients were similar. In addition, the serum levels of CRH, cortisol, GnRH, TRH, IL-1β and TNF-α were significantly higher (P<0.001) while TT3, TT4 were significantly lower (P<0.001) in the CTTH, FM and MDD groups relative to the controls. The FM patients showed lower value in the pituitary level of HPA and HPT axis. Conclusion: The patients with CTTH had similar patterns of memory damage and changes of the HPA and HPT axes, GnRH and pro-inflammatory cytokines with the FM and MDD patients.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords