Chronic Toxicity of Some Heavy Metals and Breast Cancer in Egyptian Females
- *Corresponding Author:
- Hend M. Abo El-Atta
Department of Forensic Medicine & Clinical Toxicology
Faculty of Medicine, Mansoura University, Egypt
Tel: 0102529360- 0502317171
Email: [email protected]
Received Date: October 01, 2011; Accepted Date: November 14, 2011; Published Date: November 16, 2011
Citation: El-Harouny MA, El-Morsi DA, Ahmed BRA, El-Atta HMA (2011) Chronic Toxicity of Some Heavy Metals and Breast Cancer in Egyptian Females. J Clinic Toxicol 1:109. doi: 10.4172/2161-0495.1000109
Copyright: © 2011 El-Harouny MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Heavy metals as environmental pollutants have been recognized to have a role in induction of malignant human growths. Recently, certain heavy metals showed a close association to breast cancer. This research was conducted to find out the role of some toxic heavy metals (cadmium, iron, copper, lead and zinc) in induction of breast cancer in-vivo. The study was carried out on 100 female patients: 75 with breast cancer (cancerous group) and 25 with benign breast diseases (non-cancerous group). Patients were chosen from those attending to the Oncology Center, Mansoura University. Heavy metals concentrations were measured in the urine and breast tissue samples using inductive coupled plasma (ICP) - spectrometer. The present results showed a significant increase in urine and tissue cadmium concentrations and urine copper concentration in cancerous patients compared to their corresponding non-cancerous ones (p < 0.05). Also, there was a significant reduction in iron concentration in urine samples of cancerous group compared to their corresponding non-cancerous one (p < 0.05). On the other hand, lead had no significant difference between cancerous and non cancerous groups but it was generally high in the tissue samples while zinc had no significant difference between studied groups. It could be concluded that the present study posits a causal association between cadmium and copper increase with reduction of iron and breast cancer.