alexa Circadian Rhythm Sleep Disorder in Alzheimer's Disease-A consideration in relation with the Neuropathological and Neuroendocrinal alternation- | OMICS International | Abstract
ISSN: 2168-975X

Brain Disorders & Therapy
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Short Communication

Circadian Rhythm Sleep Disorder in Alzheimer's Disease-A consideration in relation with the Neuropathological and Neuroendocrinal alternation-

Miki Umetsu1, Kentaro Fukumoto1*, Shigeru Sakurai2 and Akio Sakai1
1Department of Neuropsychiatry, School of Medicine, Iwate Medical University, Iwate, Japan
2Division of Behavioral Sleep Medicine, School of Medicine, Iwate Medical University, Iwate, Japan
Corresponding Author : Kentaro Fukumoto
Department of Neuropsychiatry
School of Medicine
Iwate Medical University
wate,020-8505,Japan
Tel: +81 19-651-5111
Fax: +81 19-626-4807
E-mail: [email protected]
Received April 03, 2014; Accepted May 19, 2014; Published May 25, 2014
Citation: Umetsu M, Fukumoto K, Sakurai S, Sakai A (2014) Circadian Rhythm Sleep Disorder in Alzheimer’s Disease. Brain Disord Ther 3:124. doi:10.4172/2168-975X.1000124
Copyright: © 2014, Umetsu M et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

?The Circadian rhythm sleep disorder of the dementia is apt to cause night wandering, delirium and even sundowning syndrome. And these behaviors put a major burden on the patients themselves and their caregivers. The ratio of complication of Circadian rhythm sleep disorder in Alzheimer's disease, the major figure of dementia, is considerably high. Circadian rhythm sleep disorder in Alzheimer's disease is supposed to be caused by physiological change of the internal secretion rhythm, physical disorder and/or environmental factors. Furthermore, in recent years, in addition to the high rate of coexistence, it has been reported that there may be essential relation between circadian rhythm sleep disorder and Alzheimer's disease. In the present study, we summarized the role of neuropathological and neuroendocrinal alternation in Circadian rhythm sleep disorder of Alzheimer's disease.

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