alexa Circulating miRNAs from Dried Blood Spots are Associated with High Altitude Sickness
ISSN: 2168-9784

Journal of Medical Diagnostic Methods
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Research Article

Circulating miRNAs from Dried Blood Spots are Associated with High Altitude Sickness

Norman E Buroker1*#, Xue-Han Ning1,2#, Zhao-Nian Zhou3#, Kui Li4, Wei-Jun Cen4#, Xiu-Feng Wu3#, Wei-Zhong Zhu3,5#, C Ronald Scott1# and Shi-Han Chen1#
1Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
2Division of Cardiology, Seattle Children’s Hospital, Institute, Foundation, Seattle, WA 98105, USA
3Laboratory of Hypoxia Physiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
4People’s Hospital of the Tibet Autonomous Region, Lhasa, China
5Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle, WA 98105, USA
#All authors contributed equally to this work
Corresponding Author : Norman E Buroker
Department of Pediatrics, University of Washington
Seattle, WA 98195, USA
E-mail: [email protected]
Received May 05, 2013; Accepted June 29, 2013; Published July 24, 2013
Citation: Buroker NE, Ning XH, Zhou ZN, Li K, Cen WJ, et al. (2013) Circulating miRNAs from Dried Blood Spots are Associated with High Altitude Sickness. J Med Diagn Meth 2:125. doi:10.4172/2168-9784.1000125
Copyright: © 2013 Buroker NE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Circulating miRNAs isolated from dried blood spots (DBS) were found to be associated with high altitude sickness (HAS) patients in Tibet. HAS arises from two different diseases which are acute (AMS) and chronic (CMS) mountain sickness. Circulating miRNAs differences were found between AMS Han Chinese patients and normal Han controls and between CMS Tibetan Chinese patients and normal Tibetan controls. HAS arises from hypoxia which afflicts some high altitude inhabitants or visitors and not others. The difference results from each individual’s genetic makeup where hypoxia related genes have been shown to be a major contributor to these sicknesses. Several fold changes increases (up regulation) were found in the hypoxia associated miRNAs let-7f-5p, miR-9-5p, miR-19a-3p, miR-23a-3p, miR-98-5p, miR-125a-5p, miR-181b-5p, mir-202-3p, miR-372, miR-381-3p, miR-519d, miR-520d-3p, and miR-656 for both HAS groups compared to their controls. Other miRNAs (miR-19a-3p, 302c-3p and 875-3p) were found to be up regulated in one HAS group and down regulated in the other HAS group indicating the genetic differences between the two sickness groups.

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