alexa Circulating miRNAs: Potential Biomarkers for Diagnosis
ISSN: 2329-6917

Journal of Leukemia
Open Access

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Mini Review

Circulating miRNAs: Potential Biomarkers for Diagnosis and Prognosis Prediction of Hematological Malignancies

Zhaolei Cui and Donghong Lin*

Department of Clinical Laboratory, School of Medical Technology and Engineering, Fujian Medical University, China

*Corresponding Author:
Donghong Lin
Department of Clinical Laboratory
School of Medical Technology and Engineering
Fujian Medical University, 88 Jiaotong Road
Taijiang, Fuzhou, Fujian 350004, P.R. China
Tel: +86059183569212
E-mail: [email protected]

Received date: June 09, 2014; Accepted date: June 20, 2014; Published date: July 02, 2014

Citation: Cui Z, Lin D (2014) Circulating miRNAs: Potential Biomarkers for Diagnosis and Prognosis Prediction of Hematological Malignancies. J Leuk (Los Angel) 2:140. doi: 10.4172/2329-6917.1000140

Copyright: © 2014 Cui Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

MicroRNAs (miRNAs) are small non-coding, single-stranded, endogenous RNAs of 19-25nt in length. They are readily detected in body fluids including serum, plasma, urine, saliva, even circulating cancer cells. With the salient features as high stability, low cost, repeatability of sampling and minimal invasiveness, circulating miRNAs are ideal for development into diagnostic tests. Emerging evidences indicated that circulating miRNAs exert a role as noninvasive biomarkers for cancer diagnostic and prognostic indexes with prospective. In this mini review, emphasis will be given to the application of plasma or serum miRNAs as biomarkers for hematological malignancies focusing on the usefulness for diagnosis and prognosis.

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