alexa Cisplatin and Concomitant Radiotherapy Followed by Chemotherapy.Towards an Optimal Adjuvant Therapy Protocol for High-risk Endometrial Cancer Patients
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Cisplatin and Concomitant Radiotherapy Followed by Chemotherapy.Towards an Optimal Adjuvant Therapy Protocol for High-risk Endometrial Cancer Patients

Aly Azmy*, Sherif Abdelwahab, Hany Abdel-Aziz and Hatem Salim

Department of Radiation Oncology & Nuclear Medicine, Ain Shams University, Egypt

*Corresponding Author:
Aly M Azmy
Department of Radiation Oncology & Nuclear Medicine
Ain Shams University, Egypt
E-mail: [email protected]

Received date: December 02, 2011; Accepted date: December 19, 2011; Published date: December 21, 2011

Citation: Azmy A, Abdelwahab S, Abdel-Aziz H, Salim H (2012) Cisplatin and Concomitant Radiotherapy Followed by Chemotherapy. Towards an Optimal Adjuvant Therapy Protocol for High-risk Endometrial Cancer Patients. J Cell Sci Ther 3:114. doi: 10.4172/2157-7013.1000114

Copyright: © 2012 Azmy A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: As there are no current definite guidelines, there is still much debate about the best adjuvant therapy after surgery for endometrial cancer (EC). Radiotherapy (RT) alone does not seem to improve overall survival. We investigated whether concomitant Cisplatin (C) and RT gave better clinical results. Patients and methods: Ninety four patients with high-risk EC (stage II, IIIA or IB G3 without lymphadenectomy) underwent primary surgery and were then referred for adjuvant therapy. Cisplatin was given at a dose of 40 mg/m2 once weekly for five weeks during RT, which consisted of a total radiation dose of 50.4 Gy. Two cycles of cisplatin 75 mg/m2 and paclitaxel 175 mg/m2 were given after finishing the radiotherapy. Overall survival and disease-free survival were calculated from the time of surgery. Patterns of failure were recorded by the sites of failure. Results: Median overall Survival was 36 months. Median time to recurrence was 26 months (range 3-37). Relapses occurred in twenty nine patients (30.8%). Adverse events were mild with three cases having grade 3 neutropenia. Local recurrence was encountered in 14% and distant metastases in 8%. Conclusion: This phase II study demonstrates pelvic radiotherapy in combination with weekly cisplatin followed by two cycles of consolidation chemotherapy as a tolerable and efficient combined approach in high risk endometrial carcinoma patients.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version