alexa Cisplatin Induced Hypomagnesemic Hypocalcemia-A Case Report and a Review of the Pathophysiology | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Cisplatin Induced Hypomagnesemic Hypocalcemia-A Case Report and a Review of the Pathophysiology

Njoh RF*, Nguyen A and Sadigh M
Saint Mary’s Hospital, Waterbury Connecticut, USA
Corresponding Author : Njoh RF
Saint Mary’s Hospital, Waterbury Connecticut, USA
E-mail: [email protected]
Received January 13, 2013; Accepted March 12, 2013; Published March 14, 2013
Citation: Njoh RF, Nguyen A, Sadigh M (2013) Cisplatin Induced Hypomagnesemic Hypocalcemia-A Case Report and a Review of the Pathophysiology. J Clin Case Rep 3:259. doi:10.4172/2165-7920.1000259
Copyright: © 2013 Njoh RF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We present a case of a 62 year old man with history of small cell lung cancer status post radiation and chemotherapy with cisplatin and etoposide who presented to the emergency room with complaints of generalized repetitive muscle contractions. His physical examination was notable for involuntary rhythmic muscle contractions of face, neck, upper arms, thigh and hyperreflexia. Laboratory data was significant for calcium 4.6 mg/dl (corrected 5.64 mg/dl), albumin 2.7 g/dl, and magnesium 0.7 mg/dl. He was treated aggressively with intravenous magnesium and calcium with resolution of symptoms. Hypomagnesemia with subsequent hypocalcemia is a common side effect of cisplatin therapy, an understanding of its pathophysiology is imperative for clinician.

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