alexa Citicholine: Current Role in Ishemic Stroke and Future Perspectives | OMICS International | Abstract
ISSN: 2329-6895

Journal of Neurological Disorders
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Review Article

Citicholine: Current Role in Ishemic Stroke and Future Perspectives

Muhammad Uwais Ashraf*, Mohd Aslam, Mohammad Shoaib Zaheer, Muzaffar Urooj Rabbani and Juwairia Ashraf
J N Medical College, Aligarh Muslim University, Aligarh, India
Corresponding Author : Muhammad Uwais Ashraf
Department of Medicine
J N Medical College
Aligarh Muslim University
Aligarh, India
Tel: + 09760159391
Email: [email protected]
Received April 28, 2014; Accepted June 03, 2014; Published June 06, 2014
Citation: Ashraf MU, Aslam M, Zaheer MS, Rabbani MU, Ashraf J (2014) Citicholine: Current Role in Ishemic Stroke and Future Perspectives. J Neurol Disord 2:165. doi: 10.4172/2329-6895.1000165
Copyright: © 2014 Ashraf MU, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Stroke is one of the leading causes of morbidity and mortality in the world and in recent years a lot of emphasis has been given to the role of newer drugs in stroke which increase neuroprotection. Citicholine (CDP-Choline; or Cytidine 5’-Diphosphocholine) has been shown to possess efficacy in the management of cognitive impairment in stroke as well as in Alzheimer’s disease. It has been demonstrated to be a neuroprotective as well as a neuroregenerative agent in patients of acute stroke. A large number of animal studies and clinical trials exist to support the efficacy of this drug in ischemic stroke and Alzheimer’s disease. Few studies have also shown its efficacy in hemorrhagic stroke and Traumatic Brain Injury (TBI). The main effects of citicholine are due to the modification of lipid metabolism in neuronal membranes. It regenerates the levels of phosphatidylcholine in the brain and improves neuronal functions. The drug is relatively safe with a very few side-effects

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