alexa Classical Neurotransmitters and Neuropeptides Involved in Major Depression: A Multi-Neurotransmitter System
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication

Classical Neurotransmitters and Neuropeptides Involved in Major Depression: A Multi-Neurotransmitter System

Werner FM1 and Covenas R2

1Euro Akademie Pößneck, Pößneck, Germany and Institute of Neuroscience of Castilla and León (INCYL), Laboratory 14, Salamanca, Spain

2Institute of Neuroscience of Castilla and León (INCYL), Laboratory 14, Salamanca, Spain

*Corresponding Author:
Felix-Martin Werner
Euro Akademie Pößneck, Pößneck
Germany and Institute of Neuroscience of Castilla and León (INCYL)
Laboratory 14, Salamanca, Spain
Tel: 00493647505520
E-mail: [email protected]

Received Date: Mar 06, 2014; Accepted Date: June 06, 2014; Published Date: June 08, 2014

Citation: Werner FM, Covenas R (2014) Classical Neurotransmitters and Neuropeptides Involved in Major Depression: A Multi-Neurotransmitter System. J Cytol Histol 5:253. doi: 10.4172/2157-7099.1000253

Copyright: © 2014 Werner, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In major depression, in both midbrain and hippocampus a hypoactivity of monoamines (serotonin, noradrenalin, dopamine) and a hypoactivity of presynaptic inhibitory neurotransmitters (GABA, glutamate) occurs. Serotonin hypoactivity, which is partly explained by polymorphisms of the serotonin transporter gene, could be as well due to an enhanced presynaptic inhibition carried out by glutaminergic neurons via m5Glu receptors. Noradrenalin hypoactivity is also due to an enhanced presynaptic inhibition exerted, via GABAB receptors, by GABAergic neurons. We derived neural networks from direct and reciprocal correlations between neurotransmitters. The neural networks presented here suggest a multimodal antidepressant pharmacotherapy by combining enhancing and antagonistic antidepressant drugs, for example noradrenalin reuptake inhibitors and GABAB antagonists.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords