alexa Cleft Lip and Palate: Etiology, Epidemiology, Preventive and Intervention Strategies | OMICS International
ISSN: 2161-0940

Anatomy & Physiology: Current Research
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Review Article

Cleft Lip and Palate: Etiology, Epidemiology, Preventive and Intervention Strategies

Eman Allam1,2* and Cynthia Stone3

1Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, IN, USA

2Oral and Dental Research Division, National Research Centre, Cairo, Egypt

3Department of Health Policy and Management, School of Public Health at IUPUI, Indianapolis, IN, USA

*Corresponding Author:
Eman Allam
Department of Oral Biology, Indiana University School of Dentistry
1121 West Michigan Street, DS 271
Indianapolis, IN 46202, USA
Tel: 317-274-1448
Fax: 317-278-1411
E-mail: [email protected]

Received date: June 24, 2014; Accepted date: July 29, 2014; Published date: July 31, 2014

Citation: Allam E, Stone C (2014) Cleft Lip and Palate: Etiology, Epidemiology, Preventive and Intervention Strategies . Anat Physiol 4: 150. doi: 10.4172/2161-0940.1000150

Copyright: © 2014 Allam E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Cleft lip and palate represent a major public health problem due to the possible associated life-long morbidity, complex etiology, and the extensive multidisciplinary commitment required for intervention. It affects about 1.5 per 1000 live births (250,000 new cases per year) worldwide, with tremendous variations across geographic areas and ethnic groups. It is considered a debilitating condition that is associated with significant feeding, hearing, speech, and psychological impairments. The wide surgical, dental, speech, social, and medical involvement emphasize the importance of understanding the underlying determinants of these defects to allow optimizing the treatment options and predicting the long-term course of the affected individuals development. Optimal and early surgical intervention is necessary and folic acid supplementation proved to be a highly efficient preventive strategy. However, there are still many challenges to be addressed for cleft care especially in the developing parts of the world.

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