alexa Clinical and Hematological Profile of Acute Myeloid Leukemia (AML) Patients of Sindh
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
Open Access

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Research Article

Clinical and Hematological Profile of Acute Myeloid Leukemia (AML) Patients of Sindh

Farzana Chang1*, Tahir Sultan Shamsi2 and Ali Muhammad Waryah1
1Molecular Biology and Genetics Department, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
2Department of Blood Transfusion, National Institute of Blood Disease and Bone Marrow Transplantation (NIBD), Karachi, Pakistan
*Corresponding Author : Dr. Farzana Chang
Associate Professor
Department of Pathology
Liaquat University of Medical and Health Sciences
Jamshoro, Pakistan
Tel: 022-9213315
E-mail:
[email protected]
Rec date: March 10, 2016; Acc date: March 31, 2016; Pub date: April 7, 2016
Citation: Chang F, Shamsi TS, Waryah AM (2016) Clinical and Hematological Profile of Acute Myeloid Leukemia (AML) Patients of Sindh. J Hematol Thrombo Dis 4:239. doi:10.4172/2329-8790.1000239
Copyright: © 2016 Chang F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

In Acute Myeloid Leukemia (AML) patients, a diversity of clinical and hematological parameters has been examined for possible value in calculating treatment response and survival. The study was conducted at National Institute of Bone Diseases, Karachi (NIBD), Sind, Pakistan, a tertiary care and teaching hospital, affiliated with Liaquat University of Medical and Health Sciences, Jamshoro. This study included 107 cases of de novo AML, both male and female patients of ages between 10-60 years were selected randomly. The clinical features included fever, weakness, loss of weight, vomiting, bleeding gums, liver and spleen enlargement, lymph node enlargement. The Laboratory investigations included CBC (Complete Blood Count) specifically heamoglobin percentage, total leucocyte count, platelet count and blast count: peripheral blood smears, bone marrow aspiration biopsy, trephine biopsy, cytochemistry (Myeloperoxidase Staining, Immunohistochemistry (CD markers)) and DNA extraction for genetic sequencing. Percentage, validity and cumulative index were calculated of all parameters. It was found that about 70% of AML patients were adults and FAB subtype M2 of acute myeloid leukemia was more prevalent than other subtypes, followed by AML, M1.

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