alexa Clinical and Histologic Comparison of Conjunctival Changes Induced by Antiglaucoma Beta Blockers, Carbonic Anhydrase Inhibitors, Alfa Agonists and Fixed Combinations with and without Preservatives | Abstract
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Clinical and Histologic Comparison of Conjunctival Changes Induced by Antiglaucoma Beta Blockers, Carbonic Anhydrase Inhibitors, Alfa Agonists and Fixed Combinations with and without Preservatives

Heloisa Helena Russ1*, Amalia Turner-Gianicco2, Fabiano Montiani-Ferreira3 and Leandro Lima2

1Federal University of Parana. Glaucoma Service. Centro da Visão/Hospital de Clinicas da Universidade Federal do Paraná, Brazil

2Veterinary Ophthalmolgy, Federal University of Parana, Brazil

3Veterinary Ophthalmolgy, Graduate School of Veterinary Sciences, SCA, Federal University of Parana, Brazil

*Corresponding Author:
Heloisa Helena Russ
Centro da Visão/ Hospital de Clinicas da Universidade Federal do Paraná
Rua Paster, 26- Batel. Curitiba, Paraná
CEP 80250080, Brazil
Tel: +55413523-0086
E-mail: [email protected], [email protected]

Received Date: September 14, 2016; Accepted Date: October 25, 2016; Published Date: October 27, 2016

Citation: Russ HH, Turner-Gianicco A, Montiani-Ferreira F, Lima L (2016) Clinical and Histologic Comparison of Conjunctival Changes Induced by Antiglaucoma Beta Blockers, Carbonic Anhydrase Inhibitors, Alfa Agonists and Fixed Combinations with and without Preservatives.J Clin Exp Ophthalmol 7:606. doi: 10.4172/2155-9570.1000606

Copyright: © 2016 Russ HH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The objective of this research was to evaluate and compare clinical tests, histological and immunohistochemical changes induced by antiglaucoma beta blockers, carbonic anhydrase inhibitors, alfa agonists and fixed combinations containing benzalkonium chloride (BAK) and without preservative (BAKFREE) in the conjunctiva of rabbits. A total of 60 rabbits (120 eyes), were divided into six groups, and treated during 30 days with: dorzolamide 2%+timolol maleate 0.5% BAK, dorzolamide 2%+timolol maleate 0.5%BAKFREE, brinzolamide 1% +timolol maleate 0.5% BAK, brimonidine 0.2%+timolol maleate 0.5%BAK, timolol maleate 0.5%BAK and control solution BAK. Right eyes served as controls and received no medication. Corneal touch threshold (CTT), Schirmer tear test (STT) and intraocular pressure (IOP) were measured during pre and post treatment periods. Conjunctival goblet cells density and vascular endothelium thickness (VET) were evaluated. Immunohistochemistry was used to detect reactive macrophages (RAM11), vascular endothelial inflammation (VCAM-1), and reactive T-lymphocytes (CD45RO).
Results: No differences were observed concerning CTT and STT. IOP was reduced in all drugs after treatment, except control solution BAK. No variation was noted in goblet cells density and VET after treatment in all groups. An increased macrophages response was observed after treatment with all BAK groups. Conjunctival reactive lymphocytes were increased after treatment only in dorzolamide 2%+timolol maleate 0.5%BAK.
Conclusion: Antiglaucoma beta blockers, carbonic anhydrase inhibitors and fixed combinations appear to have a small influence in the clinical ophthalmic tests, but with alteration in macrophage inflammatory response. The reactive macrophage stimulation was associated with the presence of preservative BAK that may induce changes in rabbit's healthy conjunctiva, trends to increase an inflammatory response. Lymphocytic inflammatory response was observed only in animals treated with dorzolamide 2%+timolol maleate 0.5%BAK, suggesting some toxic effect of this association, during 30 days treatment.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7