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Clinical and Histopathological Characteristics of Genital Melanocytic Nevi: A Report of 109 Cases and a Review of the Literature | OMICS International | Abstract
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Research Article

Clinical and Histopathological Characteristics of Genital Melanocytic Nevi: A Report of 109 Cases and a Review of the Literature

Samira Yarak1,2,3, Nilceo Schwery Michalany2, Thais Heinke2* and Joao Noberto Stavale2

1Department of Dermatology, Universidade Federal do Vale do São Francisco (UNIVASF), Brazil

2Department of Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), Brazil

3Dermatologist Collaborator of the Departament of Dermatology (EPM-UNIFESP)

*Corresponding Author:
Thais Heinke
Rua Miro vetorazzo 115 casa 115 Demarchi
Sao Bernardo do Campo SP, Brazil
Tel: 09820-135 55-11-23552003
E-mail: [email protected]

Received date: June 08, 2012; Accepted date: September 24, 2012; Published date: September 30, 2012

Citation: Yarak S, Michalany NS, Heinke T, Stavale JN (2012) Clinical and Histopathological Characteristics of Genital Melanocytic Nevi: A Report of 109 Cases and a Review of the Literature. J Clin Exp Dermatol Res 3:160. doi: 10.4172/2155-9554.1000160

Copyright: ©2012 Yarak S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Melanocytic lesions on the genital area are rare and poorly documented; they occur more frequently on the vulva and less often on the perineum, pubic area, and male genitalia. Genital melanocytic nevi exhibit features similar to nevi occurring on other areas of the body; in addition, they display high clinical and histopathological variability and are mostly classified as common nevi. However, a benign subtype of genital nevi that occurs in young women is known as atypical melanocytic nevi. These nevi exhibit distinct morphological characteristics that sometimes overlap with those of cutaneous melanoma.
A retrospective systematic review was performed of 111 biopsy specimens of pigmented lesions on the vulva, perineum, pubic area, penis, and scrotum collected between 1998 and 2009 to assess their clinicopathological characteristics. In this sample, there were 101 cases of common genital melanocytic nevi, two genital melanotic macules, seven atypical melanocytic nevi, and one dysplastic melanocytic nevus; no cases corresponded to cutaneous melanoma. Of the 111 patients, 14.4% were male, and 85.6% were female with a mean age of 34.3 years. The female exhibited a larger number of atypical melanocytic nevi than the males. The nevi displayed melanocytic proliferation, forming irregular and coalescent nests with a loss of cellular cohesion at several sites in the rete ridges. Cytologic atypia
was mild to moderate. Difficulties in the histological interpretation of these lesions remain to this day; thus, diagnosis relies significantly upon the experience and subjective judgment of pathologists to distinguish morphologically between atypical genital nevi and melanoma.


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