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Clinical and Morphological Factors in Evaluation of Efficacy of Facial Carcinoma Treatment by High-Energy Pulsed Neodymium Laser | OMICS International | Abstract
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
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Research Article

Clinical and Morphological Factors in Evaluation of Efficacy of Facial Carcinoma Treatment by High-Energy Pulsed Neodymium Laser

Moskalik KG1*, Turkevich EA2, Demin EV1 and Kozlov AP1

1Laboratory of High Energies, N.N.Petrov Research Institute of Oncology, Pesochny, St.Petersburg, Russia

2Department of Pathology, N.N.Petrov Research Institute of Oncology, Pesochny, St.Petersburg, Russia

*Corresponding Author:
Dr. Konstantin Moskalik
Laboratory of High Energies
N.N.Petrov Research Institute of Oncology
68 Leningradskaya Street, Pesochny
St. Petersburg, 197758, Russia
Tel: +7 812 596 6532
Fax: +7812 596 8947
E-mail: [email protected]

Received date: April 23, 2012; Accepted date: June 11, 2012; Published date: June 15, 2012

Citation: Moskalik KG, Turkevich EA, Demin EV, Kozlov AP (2012) Clinical and Morphological Factors in Evaluation of Efficacy of Facial Carcinoma Treatment by High-Energy Pulsed Neodymium Laser. J Nucl Med Radiat Ther S6:004. doi:10.4172/2155-9619.S6-004

Copyright: © 2012 Moskalik KG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: In this study the influence of clinical and morphological peculiarities of facial carcinoma on the results of treatment by means of Neodymium (Nd) laser radiation was estimated.

Methods: The light of high-energy mono pulsed Nd laser (λ = 1060 nm) was used to treat 2805 patients with 2940 histologically confirmed facial carcinoma, stages T1-2 N0 M0. Of those 2845 were classified as primary basal cell carcinoma (BCC) and 95 as squamous cells carcinoma (SCC). The patients were followed-up from 1 year to 13 years (median: 7 years) after treatment.

Results: The overall frequency of tumor recurrence after laser radiation was revealed in 2% of all irradiated tumors (median: 10.0 months). The rate of recurrence depended on type of tumors (1.9% in BCC and 5.3% in SCC), clinical peculiarities (3.5% in nodular-ulcerative and 4.5% infiltrative-ulcerative tumors), localization (3.2% in tumors located in nasolabial area) and tumor size.

Conclusion: Neodymium laser radiation is an effective method for treatment of facial carcinomas stages T1-2 N0 M0 whose results depend on tumor morphology, stage of the disease, clinical characteristics and localization

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