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Clinical and Prognostic Significance of Promoter Polymorphism (-31GC)of Anti Apoptotic Gene Survivin (BIRC5) in North India Patients with Non Small Cell Lung Cancer | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Clinical and Prognostic Significance of Promoter Polymorphism (-31GC)of Anti Apoptotic Gene Survivin (BIRC5) in North India Patients with Non Small Cell Lung Cancer

Jamsheed Javid1, AB Rashid Mir2, Imtiyaz Ahamad1, Shazia Farooq1, Prasant Yadav1, Maryam Zubari1, M Masroor1, PC Ray3, PK Julka4, Anant Mohan5, Maqbool Lone6, MA Banday7 and Alpana Saxena8*

1Research Scholar, Molecular Oncology Lab, Department of Biochemistry, Maulana Azad Medical College and Associated hospitals, New Delhi, India

2Research Scientist, Molecular Oncology Lab, Department of Biochemistry, Maulana Azad Medical College and Associated hospitals, New Delhi, India

3Director-Professor, Molecular Oncology Lab, Department of Biochemistry, Maulana Azad Medical College and Associated hospitals, New Delhi, India.

4Professor and Head, Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi, India

5Associate professor Department of Medicine, All India Institute of Medical Sciences, New Delhi, India

6Head, Department of Radiation Oncology,SKIMS, Srinagar, India

7Associate Professor, Department of Medical Oncology, SKIMS, Srinagar, India

8Director and Professor, Head, Molecular Oncology Lab, Department of Biochemistry, Maulana Azad Medical College and Associated hospitals, New Delhi, India

*Corresponding Author:
Dr. Alpana Saxena
Director, Professor and Head
Molecular Oncology Lab
Department of Biochemistry
Maulana Azad Medical College and Associated Hospitals
New Delhi, India
Tel: +91-9868937401
E-mail: [email protected]

Received date: July 25, 2012; Accepted date: August 17, 2012; Published date: August 20, 2012

Citation: Javid J, Mir R, Ahamad I, Farooq S, Yadav P, et al. (2012) Clinical and Prognostic Significance of Promoter Polymorphism (-31GC) of Anti Apoptotic Gene Survivin (BIRC5) in North India Patients with Non Small Cell Lung Cancer. J Cancer Sci Ther 4: 276-280. doi: 10.4172/1948-5956.1000155

Copyright: © 2012 Javid J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Apoptotic inhibitor gene survivin regulates apoptosis and cell cycle progression. Functional polymorphism in the promoter region of survivin influences its expression may lead to the development of several cancers including lung cancer. Our study aimed to investigate the association of survivin-31G>C polymorphism with the risk of NSCLC in Indian population.
 
Methods: A hospit al-based case control study of 136 cases and 136 age-gender matched healthy controls was performed by PCR-RFLP.
 
Results: Our findings reveal that a statistically increased risk and poor survival was associated with the BIRC5 -31CC genotype (OR 3.13, 95% CI 1.57- 6.25) compared to the genotype containing G allele GC (OR 1.22, 95% CI 0.69-2.14). In addition significant association was found with stage and distant metastasis status of NSCLC patients.
 
Conclusions: Our results conclude that the function polymorphism (-31G>C) in the promoter of survivin gene is associated with risk and susceptibility to NSCLC.

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