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ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
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Research Article

Clinical and Radiographic Heterogeneity of Interstitial Lung Disease in Systemic Sclerosis Based on Disease-Specific Autoantibodies

Tohru Takeuchi1*, Kentaro Isoda1, Kenichiro Hata1, Shuzo Yoshida1, Koji Nagai1,2, Takuya Kotani1,3, Shigeki Makino1 and Toshiaki Hanfusa1

1Department of Internal Medicine (I), Osaka Medical College, Japan

2Aino Hospital, Japan

3Yodogawa Christian Hospital, Japan

*Corresponding Author:
Tohru Takeuchi, MD
Department of Internal Medicine (I)
Osaka Medical College, Daigaku-machi 2-7
Takatsuki, Osaka 569-8686, Japan
Tel: +81-726-83-1221
Fax: +81- 726-83-1801
E-mail: [email protected]

Received date: August 20, 2013; Accepted date:September 30, 2013; Published date: October 10, 2013

Citation: Takeuchi T, Isoda K, Hata K, Yoshida S, Nagai K, et al. (2013) Clinical and Radiographic Heterogeneity of Interstitial Lung Disease in Systemic Sclerosis Based on Disease-Specific Autoantibodies. J Genet Syndr Gene Ther 4:185. doi:10.4172/2157-7412.1000185

Copyright: © 2013 Takeuchi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Patients with systemic sclerosis have the presence of several autoantibodies, some of which are systemic sclerosis-specific autoantibodies that are related to the clinical features of this disease. We retrospectively evaluated the clinical and radiological features of systemic sclerosis in patients with interstitial lung disease on the basis of these autoantibodies.

Method: This study comprised 226 patients with systemic sclerosis. We divided patients with systemic sclerosis into 5 clusters based on the systemic sclerosis-specific autoantibodies present and compared the clinical and radiological features of interstitial lung disease among these 5 systemic sclerosis clusters.

Results: Of 226 patients, interstitial lung disease was present in 73 (32.3%) patients. Clustering by Ward cluster analysis subsequently identified 5 major clusters of patients. Clusters of patients with anti-topoisomerase I antibody and without systemic sclerosis-specific autoantibodies had a higher incidence of interstitial lung disease compared to the other clusters (75.0% and 51.9%, respectively). Patients in these two clusters had higher percentages of cough and dyspnea, higher incidence of traction bronchiectasis and honeycomb-like cysts in computed tomography, and a decrease in percentage predicted of vital capacity. In contrast, patients with anti-centromere antibody had few clinical and laboratory findings and the lowest incidence of interstitial lung disease (16.8%). Patients with antiribonucleic antibody or nucleolar pattern in anti-nuclear antibody had moderate findings among the 5 clusters.

Conclusion: The results showed that there were differences in clinical and radiological findings among patients with systemic sclerosis-specific autoantibodies.


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