alexa Clinical Articularities of Drug-induced Agranulocytosis
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Clinical Articularities of Drug-induced Agranulocytosis or Severe Neutropenia in Elderly Patients

Emmanuel Andrès1*, Rachel Cottet-Mourot1, Olivier Keller1, Khalid Serraj2 and Thomas Vogel3
1Department of Internal Medicine, Diabetes and Metabolic Disorders, University Hospital of Strasbourg, Strasbourg 67000, France
2Department of Internal Medicine and Hematology, Oujda, Morocco
3Department Internal Medicine and Geriatrics, Strasbourg University Hospitals, Strasbourg, France
*Corresponding Author : Emmanuel Andrès
Department of Internal Medicine
Diabetes and Metabolic Diseases
Medical Clinic B, Civil Hospital
University Hospital of Strasbourg
1 Gate Hospital, 67091 Strasbourg Cedex, France
Tel: 33388115066
Fax: 33388116262
E-mail: [email protected]
Received date: November 23, 2015; Accessed date: January 19, 2016; Published date: January 26, 2016
Citation: Andrès E, Cottet-Mourot R, Keller O, Serraj K, Vogel T (2016) Clinical Articularities of Drug-induced Agranulocytosis or Severe Neutropenia in Elderly Patients. J Hematol Thrombo Dis 4:235. doi:10.4172/2329-8790.1000235
Copyright: © 2016 Andrès E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Agranulocytosis is a life-threatening disorder in any age and also in the elderly subjects who are receiving on the average a larger number of drugs than younger subjects. This disorder frequently occurs as an adverse reaction to drugs, particularly to antibiotics, antiplatelet agents, anti-thyroid drugs, neuroleptics or anti-epileptic agents and nonsteroidal anti-inflammatory agents. Although patients experiencing drug-induced agranulocytosis may initially be asymptomatic, the severity of the neutropenia usually translates into the onset of severe sepsis that requires intravenous broad-spectrum anti-biotherapy. In this setting, hematopoietic growth factors have been shown to shorten the duration of neutropenia. Thus with appropriate management, the mortality rate of idiosyncratic druginduced agranulocytosis is now of 5% to 10%. Today, drug-induced agranulocytosis still remains a rare event with an annual incidence from 3 to 12 cases per million of people. However, given the increased life expectancy and subsequent longer exposure to drugs, as well as the development of new agents, physicians should be aware of this complication and its management.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version