alexa Clinical Characteristics and Etiologic Analysis of Scab
ISSN: 2165-8048

Internal Medicine: Open Access
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Research Article

Clinical Characteristics and Etiologic Analysis of Scabies-Associated Glomerulonephritis

Zhenglan Gao 1, Hongfei Zhao2, Yunfeng Xia 2*, Hua Gan2and Zheng Xiang3
1Department of Nephrology, Chongqing Qijiang Peoples Hospital, Chongqing, PR China
2Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China
3Department of Nephrology, Second People's Hospital of Xuan Han, Sichuan, PR China
Corresponding Author : Yunfeng X
Department of Nephrology
The First Affiliated Hospital of Chongqing
Medical University, Yuanjiagang
Chongqing, PR China
Tel: 86-023-89012256
E-mail: [email protected]
Received: June 19, 2015 Accepted: July 08, 2015 Published:July 16, 2015
Citation:Zhenglan G, Hongfei Z, Hua G, Zheng X, Yunfeng X (2015) Clinical Characteristics and Etiologic Analysis of Scabies-Associated Glomerulonephritis. Intern Med 5: 196. doi:10.4172/2165-8048.1000196
Copyright: ©2015 Yunfeng X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Objective: Scabies-associated glomerulonephritis (SGN) is often seen in certain populations, but little is known about its incidence, clinical characteristics, prognosis and pathogenesis.

Methodology: 376 patients with scabies were enrolled and divided into scabies-alone group (group A) and SGN group (group B) based on the presence or absence of glomerulonephritis. Clinical indicators and various biomarkers, including serum C-reactive protein, complement components C3 and C4, immunoglobulin, TNF-α, IL-6, IL-1β, and IL-18 in the early stage of the disease, were determined before and after treatment. All patients were follow-up in the clinic.

Results: 16 scabies patients developed SGN in this study. The clinical manifestations included glomerular hematuria and/or mild-moderate proteinuria. The manifestations associated with kidney injury in most of these patients completely resolved 2-6 months after scabies was cured. Compared to the patients in group A, the levels of serum CRP, IgG, TNF-α, IL-6, and IL-18 increased significantly and the serum C3 level decreased significantly in the patients in group B. Twelve patients with SGN achieved a clinical cure. Compared to the early stage of the disease, the levels of serum IgG, hs-CRP, TNF-α, IL-6, and IL-18 in these patients decreased significantly after being cured, and the serum C3 level increased significantly.

Conclusions : SGN is generally mild and has a good prognosis. The mechanisms may involve the generation of specific antibodies stimulated by itch mites, triggering of excessive immune and inflammatory responses.
 

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