alexa Clinical Findings Showing that Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect| Abstract

Clinical Neuropsychology: Open Access

  • Case Study   
  • J Neuropsychopharmacol Mental Health 2017, Vol 2(1): 115

Clinical Findings Showing that Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect

Kotaro Sugita, Yasuhiro Mori, Kousuke Kanemoto and Sotaro Sugita*
Department of Neuropsychiatry, Aichi Medical University, Nagakute- shi, Japan
*Corresponding Author : Sotaro Sugita, Department of Neuropsychiatry, Aichi Medical University, P.O. 480-1195, Yazako Karimata, 1–1, Nagakute-shi, Aichi Prefecture, Japan, Tel: + 81561623311, Email: [email protected]

Received Date: Jan 09, 2017 / Accepted Date: Feb 11, 2017 / Published Date: Feb 20, 2017

Abstract

Two treatment-resistant schizophrenic patients were administered clozapine, but showed a decrease in granulocytes. As an alternative treatment, we administered non-convulsive Electric Shock Therapy (ECT) (modified- ECT: m-ECT) to both and the number of granulocytes increased to a level considered safe for clozapine ingestion. Then, under continuation of m-ECT, we gradually increased the dose of the drug. After 10-14 m-ECT sessions in both patients, the number of granulocytes became stable at approximately 5000/mm3 and m-ECT was completed. Our findings show the possibility of treatment for therapy-resistant patients who are unable to receive clozapine because of reduced granulocyte number.

Keywords: Clozapine therapy; Electric shock; Schizophrenia; Granulocytes

Citation: Sugita K, Mori Y, Kanemoto K, Sugita S (2017) Clinical Findings Showing That Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect. J Neuropsychopharmacol Mental Health 2: 115.

Copyright: © 2017 Sugita K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any Smedium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment
Share This Article
Relevant Topics
Recommended Conferences
Viewmore
Article Usage
  • Total views: 1267
  • [From(publication date): 0-2017 - Jul 20, 2018]
  • Breakdown by view type
  • HTML page views: 1203
  • PDF downloads: 64
Leave Your Message 24x7