Clinical Findings Showing That Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect
Kotaro Sugita, Yasuhiro Mori, Kousuke Kanemoto and Sotaro Sugita*
Department of Neruro-Psychiatry, Achi Medical University, Nagakute- shi, Japan
- *Corresponding Author:
- Sotaro Sugita
Department of Neruro-Psychiatry
Achi Medical University, P.O. 480-1195
Yazako Karimata, 1–1, Nagakute-shi
Aichi Prefecture, Japan
Tel: + 81561623311
E-mail: [email protected]
Received date: January 09, 2017; Accepted date: February 11, 2017; Published date: February 20, 2017
Citation: Sugita K, Mori Y, Kanemoto K, Sugita S (2017) Clinical Findings Showing That Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect. J Neuropsychopharmacol Mental Health 2:115. doi: 10.4172/2472-095X.1000115
Copyright: © 2017 Sugita K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any Smedium, provided the original author and source are credited.
Two treatment-resistant schizophrenic patients were administered clozapine, but showed a decrease in granulocytes. As an alternative treatment, we administered non-convulsive Electric Shock Therapy (ECT) (modified- ECT: m-ECT) to both and the number of granulocytes increased to a level considered safe for clozapine ingestion. Then, under continuation of m-ECT, we gradually increased the dose of the drug. After 10-14 m-ECT sessions in both patients, the number of granulocytes became stable at approximately 5000/mm3 and m-ECT was completed. Our findings show the possibility of treatment for therapy-resistant patients who are unable to receive clozapine because of reduced granulocyte number.