alexa Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina | OMICS International | Abstract
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Research Article

Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina

María Fernanda Suárez1, Nicolás Crim2, Rodolfo Monti2, Evangelina Espósito2, Julio Alberto UrretsZavalía2§, Horacio Marcelo Serra1§,*
1Department of Clinical Biochemistry, CIBICI, Faculty of Chemical Science, National University of Córdoba, Argentina
2Department of Ophthalmology, University Clinic Reina Fabiola, Catholic University of Córdoba, Argentina
§These authors equally contributed to this work
Corresponding Author : Horacio Marcelo Serra
Department of Clinical Biochemistry
CIBICI, Faculty of Chemical Science
National University of Córdoba, Haya de la
Torre esquina Medina Allende; 5000, Córdoba, Argentina
Tel +54 351 4344973
E-mail: [email protected]
Received: Sep 26, 2015 Accepted: Nov 28, 2015 Published: Dec 01, 2015
Citation: Suárez MF, Crim N, Monti R, Espósito E, UrretsZavalía JA, et al. (2015) Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina. J Clin Exp Ophthalmol 6:499. doi:10.4172/2155-9570.1000499
Copyright: © 2015 Serra HM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Objective: The purpose of our work was to study and compare the cornea and tear film of people and sheep inhabiting in a region of Argentinean Patagonia (PATG), and in a geographically and climatically different region in the Argentinean Pampa (CAPT).
Methods: Using cross sectional study, corneal examinations were performed in people and Merino sheep inhabiting PATG and CAPT regions, respectively. All people completed a questionnaire related to work activity, diet, and the use of hats or sunglasses during their life. Eyes from all participants were examined with a portable handheld slitlamp biomicroscope (BM) to evaluate corneal appearance, epithelium integrity, and transparency. Later on, in a subgroup of participants we studied eyeblinking frequency (EBF), ocular surface staining (FS), breakup time (BUT), Schirmer Tear Test (STT), corneal structure using confocal laser scanning microscopy (CLSM) and light microscopy (LM), and concentrations of serum ascorbate (sAA).
Results: BM studies revealed numerous cases of Climatic Droplets Keratopathy (CDK) only in people inhabiting the PATG region. CLSM studies confirmed typical punctiform deposits at the Bowman´s layer in CDK patients living in that region. CLSM images from sheep did not show any abnormalities at the Bowman´s layer but exhibited small hyper reflective dots at the epithelium only in animals pasturing in the PATG region. FS and EBF mean values were significant higher in sheep grazing in the PATG region (p <0.05). No differences were found in surface eye tests when people from both regions were analyzed. Low sAA levels were found only in CDK people living in PATG region.
Conclusions: CDK is a multi-factorial disease not only associated to harsh climate. We provide data that low sAA levels can play a role in its genesis in Patagonia patients’... Sheep pasturing in this region with a high prevalence of CDK have high concentration of sAA and did not present any sub epithelial corneal abnormalities.

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