Clinical Genotypic Correlation of Beta S-Globin Haplotypes in Sickle Cell AnemiaGhazi A. Damanhouri and Jummanah S. Jarullah*
Hematology Research Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia
- *Corresponding Author:
- Jummanah S. Jarullah
Hematology Research Lab
King Fahd Medical Research Center
King Abdulaziz University
P.O. Box 80216
Jeddah 21589, Saudi Arabia
Tel: 966-12-640-0000, extn. 25020
E-mail: [email protected]
Received date: December 17, 2015; Accepted date: January 18, 2016; Published date: January 22, 2016
Citation: Damanhouri GA, Jarullah JS (2016) Clinical Genotypic Correlation of Beta S-Globin Haplotypes in Sickle Cell Anemia. J Blood Disord Transfus 7:335. doi:10.4172/2155-9864.1000335
Copyright: © 2016 Damanhouri GA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sickle cell disease played a pioneering role in the establishment of the field of molecular medicine. Even though this disease was identified many years ago its clinical course is still not clear. Clinical severity ranges across individuals, even within the same ethnic group. Molecular studies have identified different haplotypes across the globin gene cluster. Correlating individual haplotypes with clinical severity has become the primary focus in the endeavour to establish a successful treatment. Even though numerous studies have been performed, most have shown a negative correlation between beta S-globin haplotypes and clinical phenotype. After a review of recent medical literature, the authors conclude that further research translating genetic analysis to positive therapeutic response for sickle cell disease patients is needed.