Clinical Impact of Radiation-Resistant Mesenchymal Stem Cells in Bone Marrow Deduced from Preclinical StudiesYuichi Michikawa MasaharuHazawa Ai Saotome-Nakamura Takeshi Yasuda Takaya Gotoh Katsushi Tajima*
Research Program for Radiation Emergency Medicine, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage, Chiba, 263-8555, Japan
- Corresponding Author:
- Katsushi Tajima, MD, PhD
Research Program for Radiation Emergency Medicine
Research Center for Radiation Emergency Medicine
National Institute of Radiological Sciences
Anagawa 4-9-1, Inage, Chiba, 263-8555, Japan
E-mail: [email protected]
Received Date: January 07, 2013; Accepted Date: February 01, 2013; Published Date: February 16, 2013
Citation: Michikawa Y, Hazawa M, Saotome-Nakamura A, Yasuda T, Gotoh T, et al. (2013) Clinical Impact of Radiation-Resistant Mesenchymal Stem Cells in Bone Marrow Deduced from Preclinical Studies. J Bone Marrow Res 1:101. doi:10.4172/2329-8820.1000101
Copyright: © 2013 Michikawa Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mesenchymal stem cells in the bone marrow have attracted great interest over the past decades, not only as a basic scientific subject but also as a novel and advanced clinical tool. More than 100 mesenchymal stem cell-related clinical trials are currently registered in the world. Hematopoietic stem cells in bone marrow are extremely radiationsensitive, whereas mesenchymal stem cells show considerable radiation-resistance. Intrinsic cellular mechanisms, including highly efficient reactive oxygen species-scavenging ability and active DNA damage response pathways, have been reported to explain the radiation-resistance of mesenchymal stem cells in the bone marrow. The precise interactions between residual host mesenchymal stem cells and donor mesenchymal stem cells at the time of bone marrow transplantation following whole-body irradiation, however, remain unknown. This short review summarizes our current understanding of the clinical impact of the radiation-resistance of endogenous mesenchymal stem cells in the bone marrow.