alexa Clinical Significance of Circulating Tumor Cells in Pancreatic Cancer
ISSN: 0974-8369

Biology and Medicine
Open Access

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Research Article

Clinical Significance of Circulating Tumor Cells in Pancreatic Cancer

Guangfu Li1,2*, Yue Huang1,2, Yariswamy Manjunath1,2, Eric T Kimchi1,2, Jussuf T Kaifi1,2 and Kevin F Staveley-O’Carroll1,2,3*

1Department of Surgery, University of Missouri, Columbia, Missouri, United States of America

2Ellis Fischel Cancer Center, University of Missouri, Columbia, Missouri, United States of America

3Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, Missouri, United States of America

*Corresponding Author:
Guangfu Li, Ph.D, DVM
Assistant Professor, Department of Surgery
Ellis Fischel Cancer Center, The University of Missouri
One Hospital Drive, Columbia
Missouri 65212, United States of America
Tel: 573-882-8454
Fax: 573-884-6054
E-mail: [email protected]

Kevin F Staveley-O’Carroll, M.D, Ph.D
Professor and Chair of Surgery
Director of Ellis Fischel Cancer Center
The University of Missouri, One Hospital Drive
Columbia, Missouri 65212, United States of America
Tel: 573-882-8454
Fax: 573-884-6054
E-mail: [email protected]

Received Date: October 29, 2016; Accepted Date: November 17, 2016; Published Date: November 24, 2016

Citation: Li G, Huang Y, Manjunath Y, Kimchi ET, Kaifi JT, et al. (2016) Clinical Significance of Circulating Tumor Cells in Pancreatic Cancer. Biol Med (Aligarh) 8: 357. doi:10.4172/0974-8369.1000357

Copyright: © 2016 Li G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.



Pancreatic cancer (PC) is a highly aggressive malignancy with limited therapeutic options. Early and accurate detection is critically important for successful cancer treatment. Currently, the most widely used and best validated marker for pancreatic cancer is carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA). However, inadequate sensitivity and specificity limit the use of CA 19-9 and CEA in the early screening and diagnosis of pancreatic cancer. During past ten years, circulating tumor cells (CTCs) as a new liquid biomarker have received enormous attention in cancer diagnosis and management. Although CTCs are extremely rare and challenging to be isolated, their clinical significance has extensively been investigated in numerous clinical trials. In this review, we summarize the CTC application in translational pancreatic cancer research and its outlook in the future, specifically evaluating its clinical potential in pancreatic cancer diagnosis, prognosis, and treatments. Development of sensitive, specific, and reliable methods is expected towards a major impact on our ability in cancer management.


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