Clinicopathological Significance of Fatty Acid Synthase Expression in Extrahepatic CholangiocarcinomaMaekawa Hiroshi1*, Ito Tomoaki2, Tomoyuki Kushida1, Orita Hajime1, Mutsumi Sakurada1, Sato Koichi1 and Wada Ryo2
- *Corresponding Author:
- Maekawa Hiroshi
Associate Professor, Department of Surgery
Juntendo University School of Medicine Shizuoka Hospital
1129 Nagaoka, Izu-no-kuni City
Shizuoka, 410-2295 Japan
Tel: +81 55.948.3111
E-mail: [email protected]
Received date: May 26, 2016; Accepted date: August 26, 2016; Published date: August 30, 2016
Citation: Hiroshi M, Tomoaki I, Kushida T, Hajime O, Sakurada M, et al. (2016) Clinicopathological Significance of Fatty Acid Synthase Expression in Extrahepatic Cholangiocarcinoma. Oncol Cancer Case Rep 2: 117. doi: 10.4172/2471-8556.1000117
Copyright: © 2016 Hiroshi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Here, we investigated whether FAS expression in extrahepatic cholangiocarcinoma is related to clinicopathological features. Methods: We studied 37 patients surgically treated for extrahepatic cholangiocarcinoma in our hospital. We compared FAS immunohistochemical staining with other pathological features, including Ki-67, p53 staining, and clinical findings using univariate analysis. Results: Of 37 cases, 20 cases were considered FAS-positive under our criteria. Pathologically, FAS positivity was not correlated with either Ki-67 positivity or p53 positivity (p: 0.1099, 0.0878). FAS expression was not related to differentiation of adenocarcinoma (p: 0.9350). However, a higher rate of FAS-positive cases was found in lymph node metastases (p: 0.0102). Clinically, FAS-positive cases showed earlier recurrence compared to FAS-negative cases (p: 0.0238); though there was no significant difference in overall survival rate between FAS-positive and FAS-negative cases (p: 0.1398). Conclusion: FAS expression may be related to lymph node metastasis and clinical behavior in extrahepatic cholangiocarcinoma, and may be useful as a prognostic marker of this cancer.