Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time
- *Corresponding Author:
- Pawel Jozkow
Department of Sports Medicine
University School of Physical Education
ul. Paderewskiego 35, 51-612 Wroclaw, Poland
Tel: +48 71 347 33 06
Fax: +48 71 347 30 53
Received date: February 27, 2014; Accepted date: April 23, 2014; Published date: April 30, 2014
Citation: Medras M, Jozkow P, Terpilowski L, Zagocka E (2014) Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time. J Steroids Hormon Sci 5:129. doi:10.4172/2157-7536.1000129
Copyright: © 2014 Medras M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Androgenic-anabolic steroids (AAS) are commonly used by athletes and recreational athletes. In some cases they induce persistent anabolic steroid-induced hypogonadism (ASIH).
Design: In an observational study we assessed the function of the pituitary-gonadal axis in a series of men with suspected ASIH.
Methods: Clomiphene stimulation test (CST) was performed in 13 hypogonadal adult men with previous, prolonged exposure to AAS. We evaluated the response of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and total testosterone (T) to 50 mg of clomiphene daily administered for a week.
Results: Mean concentrations of hormones before and after clomiphene administration were respectively (mean ± SD): 3 ± 1.2 and 8.3 ± 2 mIU/ml for LH; 3 ± 1.1 and 10 ± 14.6 mIU/ml for FSH; and 2.3 ± 0.6 and 7.2 ± 1.7 ng/ml for T (p<0.001).
Conclusions: Men with ASIH, after a long-time withdrawal of AAS, present an intact reaction of gonadotropins and testosterone to clomiphene stimulation.