alexa Clomiphene Stimulation Test in Men Abusing Anabolic-And
ISSN: 2157-7536

Journal of Steroids & Hormonal Science
Open Access

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Research Article

Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time

Medras M1,2, Jozkow P2*, Terpilowski L3 and Zagocka E4

1Department of Endocrinology, Diabetology and Isotope Treatment, Wroclaw Medical University, ul. Pasteura 4, 50-367 Wroclaw, Poland

2Department of Sports Medicine, University School of Physical Education, ul, Paderewskiego 35, 51-612 Wroclaw, Poland

3Department of Emergency Medical Services, Wroclaw Medical University, ul. Pasteura 4, 50-367 Wroclaw, Poland

4Laboratory of Male Infertility, ul. Kosciuszki 108A/18, 50-441 Wroclaw, Poland

*Corresponding Author:
Pawel Jozkow
Department of Sports Medicine
University School of Physical Education
ul. Paderewskiego 35, 51-612 Wroclaw, Poland
Tel: +48 71 347 33 06
Fax: +48 71 347 30 53
E-mail: jozkow@gmail.com

Received date: February 27, 2014; Accepted date: April 23, 2014; Published date: April 30, 2014

Citation: Medras M, Jozkow P, Terpilowski L, Zagocka E (2014) Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time. J Steroids Hormon Sci 5:129. doi:10.4172/2157-7536.1000129

Copyright: © 2014 Medras M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: Androgenic-anabolic steroids (AAS) are commonly used by athletes and recreational athletes. In some cases they induce persistent anabolic steroid-induced hypogonadism (ASIH).

Design: In an observational study we assessed the function of the pituitary-gonadal axis in a series of men with suspected ASIH.

Methods: Clomiphene stimulation test (CST) was performed in 13 hypogonadal adult men with previous, prolonged exposure to AAS. We evaluated the response of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and total testosterone (T) to 50 mg of clomiphene daily administered for a week.

Results: Mean concentrations of hormones before and after clomiphene administration were respectively (mean ± SD): 3 ± 1.2 and 8.3 ± 2 mIU/ml for LH; 3 ± 1.1 and 10 ± 14.6 mIU/ml for FSH; and 2.3 ± 0.6 and 7.2 ± 1.7 ng/ml for T (p<0.001).

Conclusions: Men with ASIH, after a long-time withdrawal of AAS, present an intact reaction of gonadotropins and testosterone to clomiphene stimulation.

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