alexa Clues to the Pathogenesis of Melasma from its Histologic Findings | OMICS International | Abstract
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
Open Access

Like us on:

Previously: Journal of Pigmentary Disorders

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Clues to the Pathogenesis of Melasma from its Histologic Findings

Soon-Hyo Kwon1,2 and Kyoung-Chan Park1,2*
1Seoul National University, College of Medicine, Korea
2Seoul National University, Bundang Hospital, Gyeonggi, Korea
Corresponding Author : Kyoung Chan Park, MD
Department of Dermatology
Seoul National University College of Medicine
Seoul National University, Bundang Hospital
300 Gumi-dong, Bundang-gu, Seongnam-si
Gyeonggi-do 463-707, Korea
Tel: +82-31-787-7311
Fax: +82-31-787-4058
E-mail: [email protected]
Received July 08, 2014; Accepted October 17, 2014; Published October 19, 2014
Citation: Kwon SH, Park KC (2014) Clues to the Pathogenesis of Melasma from its Histologic Findings. Pigmentary Disorders 1:141. doi:10.4172/2376-0427.1000141
Copyright: © 2014 Kwon SH, et al. The terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Melasma is a common acquired hypermelanosis that affects sun-exposed areas of the skin, especially the face. Its histologic manifestations are evident in the epidermis, extracellular matrix, and dermis. One of the hallmarks of melasma is an increase in the amount of epidermal melanin; however, whether melanocyte numbers increase or not is a topic of debate. Interestingly, basement membrane abnormalities also characterize melasma. Furthermore, solar elastosis is recognized as one of the dermal pathologic findings of melasma. These findings suggest that extracellular matrix abnormalities are consistently found in melasma. In the dermis, increased vascularity and increases in mast cell numbers are observed, indicating that dermal factors have important roles in the pathogenesis of melasma, despite melasma being characterized by epidermal hyperpigmentation. This review discusses these histologic characteristics of melasma, and it considers their implications for the pathogenesis of this skin condition.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7